Acute kidney injury in critically ill children with COVID-19 and MIS-C

Background This study’s objective was to investigate the incidence of acute kidney injury (AKI) in children with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and multisystem inflammatory syndrome (MIS-C) and to report our clinical experience. Methods Acute COVID-19 and MIS-C-diagnosed patients observed in two pediatric intensive care units (PICUs) between 2019 and 2021 were examined for AKI and retrospectively compared to children with AKI. Results The study comprised 163 children, of whom 98 (60.1%) were diagnosed with acute COVID-19 and 65 (39.9%) with MIS-C. AKI was observed in 40 (40.8%) of the acute COVID-19 patients and 18 (27.7%) of the MIS-C patients. Low calcium level and hypotension were linked with AKI at initial presentation (OR: 0.56, 95% CI: 0.369–0.560, p = 0.006 and OR: 3.64, 95% CI: 1.885–7.152, p = 0.001, respectively). A history of nephrotoxic medication usage played an essential role in the development of AKI in patients who acquired AKI after hospitalization (p = 0.001, odds ratio: 9.32, confidence interval: 3.106–27.973). In clinical practice, individuals with respiratory distress and cough had a high chance of having AKI (OR: 4.47, 95% confidence interval: 2.25–8,892 and OR: 3.48, 95% confidence interval: 1.76–6.88). AKI patients had a greater demand for respiratory assistance and a longer period of stay in the PICU. Conclusions AKI in the COVID-19 and MIS-C patient groups is related with increased mortality and extended hospitalization, according to the findings. These statistics imply that identifying and preventing risk factors is necessary. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information.

Medienart:

E-Artikel

Erscheinungsjahr:

2023

Erschienen:

2023

Enthalten in:

Zur Gesamtaufnahme - volume:38

Enthalten in:

Pediatric nephrology - 38(2023), 10 vom: 12. Mai, Seite 3475-3482

Sprache:

Englisch

Beteiligte Personen:

Özen, Hasan [VerfasserIn]
Aslan, Ayşen Durak [VerfasserIn]
Balaban, Burak [VerfasserIn]
Perk, Oktay [VerfasserIn]
Uçmak, Hacer [VerfasserIn]
Özcan, Serhan [VerfasserIn]
Gurbanov, Anar [VerfasserIn]
Uyar, Emel [VerfasserIn]
Kahveci, Fevzi [VerfasserIn]
Gün, Emrah [VerfasserIn]
Tehci, Ali Kansu [VerfasserIn]
Emeksiz, Serhat [VerfasserIn]
Kendirli, Tanıl [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

Themen:

Acute kidney injury
Multisystem inflammatory syndrome
Pediatric intensive care
SARS-CoV-2

Anmerkungen:

© The Author(s), under exclusive licence to International Pediatric Nephrology Association 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s00467-023-05987-x

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2145280626

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