Efficacy and feasibility of scheduled intravenous acetaminophen administration after pancreatoduodenectomy: a propensity score-matched study
Purpose The efficiency and safety of routine intravenous administration of acetaminophen after highly invasive hepatobiliary pancreatic surgery remain unclear. In particular, there have been no studies focusing on pancreatoduodenectomy. The present study clarified its clinical utility for patients undergoing pancreatoduodenectomy. Methods We retrospectively collected 179 patients who underwent open pancreatoduodenectomy from 2015 to 2020. The analgesic effects and adverse events in patients with scheduled intravenous administration of acetaminophen were evaluated using propensity score matching. Results After 40 patients from each group were selected by propensity score matching, the postoperative liver function tests were not significantly different between the control and acetaminophen groups. No significant differences were found in the self-reported pain intensity score or postoperative nausea and vomiting; however, the rate of pentazocine use and the total number of additional analgesics were significantly lower in the acetaminophen group than in the control group (p = 0.003 and 0.002, respectively). Conclusion The scheduled intravenous administration of acetaminophen did not affect the postoperative liver function and had a good analgesic effect after pancreatoduodenectomy..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
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| Enthalten in: |
Surgery today - 53(2023), 9 vom: 06. Feb., Seite 1047-1056 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hirano, Katsuhisa [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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© The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| doi: |
10.1007/s00595-023-02647-3 |
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OLC2145246096 |
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| 520 | |a Purpose The efficiency and safety of routine intravenous administration of acetaminophen after highly invasive hepatobiliary pancreatic surgery remain unclear. In particular, there have been no studies focusing on pancreatoduodenectomy. The present study clarified its clinical utility for patients undergoing pancreatoduodenectomy. Methods We retrospectively collected 179 patients who underwent open pancreatoduodenectomy from 2015 to 2020. The analgesic effects and adverse events in patients with scheduled intravenous administration of acetaminophen were evaluated using propensity score matching. Results After 40 patients from each group were selected by propensity score matching, the postoperative liver function tests were not significantly different between the control and acetaminophen groups. No significant differences were found in the self-reported pain intensity score or postoperative nausea and vomiting; however, the rate of pentazocine use and the total number of additional analgesics were significantly lower in the acetaminophen group than in the control group (p = 0.003 and 0.002, respectively). Conclusion The scheduled intravenous administration of acetaminophen did not affect the postoperative liver function and had a good analgesic effect after pancreatoduodenectomy. | ||
| 650 | 4 | |a Pancreatoduodenectomy | |
| 650 | 4 | |a Acetaminophen | |
| 650 | 4 | |a ERAS | |
| 650 | 4 | |a Multimodal analgesia | |
| 700 | 1 | |a Igarashi, Takamichi |4 aut | |
| 700 | 1 | |a Murotani, Kenta |4 aut | |
| 700 | 1 | |a Tanaka, Nobutake |4 aut | |
| 700 | 1 | |a Sakurai, Taro |4 aut | |
| 700 | 1 | |a Miwa, Takeshi |4 aut | |
| 700 | 1 | |a Watanabe, Toru |4 aut | |
| 700 | 1 | |a Shibuya, Kazuto |4 aut | |
| 700 | 1 | |a Yoshioka, Isaku |4 aut | |
| 700 | 1 | |a Fujii, Tsutomu |0 (orcid)0000-0003-0625-1911 |4 aut | |
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