Details der Publikation - Clinical Utility of Albumin Bilirubin Grade as a Prognostic Marker in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization: a Systematic Review and Meta-analysis

Clinical Utility of Albumin Bilirubin Grade as a Prognostic Marker in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization: a Systematic Review and Meta-analysis

Purpose Hepatic function is a key prognostic marker in patients with hepatocellular cancer (HCC) and central to patient selection for transarterial chemoembolization (TACE). We investigated the clinical utility of the Albumin-Bilirubin (ALBI) grade, an emerging prognostic model, in this heterogenous cohort via a meta-analysis of published studies. Methods Publications including full text articles and abstracts regarding ALBI grade were sourced by two independent researchers from databases including PubMed, Embase, Medline and Cochrane Library. Studies analysing patients with HCC undergoing TACE treatment were systematically screened utilising the PRISMA tool for data extraction and synthesis, after exclusion of duplicates, irrelevant studies and overlapping cohorts. The primary outcome was overall survival (OS), as determined by ALBI grade and assessed by hazard ratio (HRs) with 95% confidence intervals (CIs), with analysis of collated data using comprehensive meta-analysis, version 3.0 software. Results Eight studies were included, with a pooled population of 6538 patients with HCC that underwent TACE treatment. Higher pre-treatment grade was associated with poor OS, with median OS of 12.0 months (P < 0.001) in ALBI grade 3, compared to 33.5 months in ALBI grade 1 (P < 0.001). Significant heterogeneity within each ALBI grade was associated with age and tumour size (P < 0.001) in ALBI grades 1 and 2. In contrast, age and alcohol–related liver disease were significant in the ALBI grade 3 group (P < 0.001). Conclusions High pre-treatment ALBI grade is associated with poorer prognosis in patients with HCC undergoing TACE therapy. The ALBI grade demonstrates clinical utility for clinical prognostication and patient selection for TACE..

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:54
Enthalten in:	Journal of gastrointestinal cancer - 54(2022), 2 vom: 30. Mai, Seite 420-432

Sprache:	Englisch

Beteiligte Personen:	Mishra, Gauri [VerfasserIn] Majeed, Ammar [VerfasserIn] Dev, Anouk [VerfasserIn] Eslick, Guy D. [VerfasserIn] Pinato, David J. [VerfasserIn] Izumoto, Hirofumi [VerfasserIn] Hiraoka, Atsushi [VerfasserIn] Huo, Teh-Ia [VerfasserIn] Liu, Po-Hong [VerfasserIn] Johnson, Philip J. [VerfasserIn] Roberts, Stuart K. [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.87 / Gastroenterologie / Gastroenterologie
Themen:	ALBI grade HCC Meta-analysis Prognosis TACE

Anmerkungen:	© Crown 2022

doi:	10.1007/s12029-022-00832-0

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2145070664

Internformat


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520			\|a Purpose Hepatic function is a key prognostic marker in patients with hepatocellular cancer (HCC) and central to patient selection for transarterial chemoembolization (TACE). We investigated the clinical utility of the Albumin-Bilirubin (ALBI) grade, an emerging prognostic model, in this heterogenous cohort via a meta-analysis of published studies. Methods Publications including full text articles and abstracts regarding ALBI grade were sourced by two independent researchers from databases including PubMed, Embase, Medline and Cochrane Library. Studies analysing patients with HCC undergoing TACE treatment were systematically screened utilising the PRISMA tool for data extraction and synthesis, after exclusion of duplicates, irrelevant studies and overlapping cohorts. The primary outcome was overall survival (OS), as determined by ALBI grade and assessed by hazard ratio (HRs) with 95% confidence intervals (CIs), with analysis of collated data using comprehensive meta-analysis, version 3.0 software. Results Eight studies were included, with a pooled population of 6538 patients with HCC that underwent TACE treatment. Higher pre-treatment grade was associated with poor OS, with median OS of 12.0 months (P < 0.001) in ALBI grade 3, compared to 33.5 months in ALBI grade 1 (P < 0.001). Significant heterogeneity within each ALBI grade was associated with age and tumour size (P < 0.001) in ALBI grades 1 and 2. In contrast, age and alcohol–related liver disease were significant in the ALBI grade 3 group (P < 0.001). Conclusions High pre-treatment ALBI grade is associated with poorer prognosis in patients with HCC undergoing TACE therapy. The ALBI grade demonstrates clinical utility for clinical prognostication and patient selection for TACE.
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700	1		\|a Majeed, Ammar \|4 aut
700	1		\|a Dev, Anouk \|4 aut
700	1		\|a Eslick, Guy D. \|4 aut
700	1		\|a Pinato, David J. \|4 aut
700	1		\|a Izumoto, Hirofumi \|4 aut
700	1		\|a Hiraoka, Atsushi \|4 aut
700	1		\|a Huo, Teh-Ia \|4 aut
700	1		\|a Liu, Po-Hong \|4 aut
700	1		\|a Johnson, Philip J. \|4 aut
700	1		\|a Roberts, Stuart K. \|4 aut
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Clinical Utility of Albumin Bilirubin Grade as a Prognostic Marker in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization: a Systematic Review and Meta-analysis

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