Severe systemic inflammation mimicking TAFRO syndrome following COVID-19

Abstract TAFRO syndrome is a rare systemic inflammatory disease. Its pathogenesis mainly involves excessive cytokine secretion and autoimmune dysfunction. Although its etiology is unclear, some viral infections have been reported to cause it. Here, we report a case of severe systemic inflammation mimicking TAFRO syndrome that arose after COVID-19. A 61-years-old woman suffered from a continuous fever, ascites, and edema after contracting COVID-19. She developed progressive thrombocytopenia, renal failure, and elevated C-reactive protein levels. She was tentatively diagnosed with multisystem inflammatory syndrome in adults (MIS-A) and received steroid pulse therapy. However, she exhibited worsening fluid retention and progressive renal failure, which are not typical of MIS-A. A bone marrow examination showed reticulin myelofibrosis and an increased number of megakaryocytes. Although a definitive diagnosis of TAFRO syndrome was not made according to current diagnostic criteria, we determined that her symptoms were clinically consistent with those of TAFRO syndrome. Combination therapy, including steroid pulse therapy, plasma exchange, rituximab, and cyclosporine, improved her symptoms. There are pathological similarities between hyperinflammation that arises after COVID-19 and TAFRO syndrome in terms of the associated cytokine storms. COVID-19 may have triggered the development of systemic inflammation mimicking TAFRO syndrome in this case..

Medienart:

E-Artikel

Erscheinungsjahr:

2023

Erschienen:

2023

Enthalten in:

Zur Gesamtaufnahme - volume:118

Enthalten in:

International journal of hematology - 118(2023), 3 vom: 31. März, Seite 374-380

Sprache:

Englisch

Beteiligte Personen:

Tane, Misato [VerfasserIn]
Kosako, Hideki [VerfasserIn]
Hosoi, Hiroki [VerfasserIn]
Tabata, Kayoko [VerfasserIn]
Hiroi, Takayuki [VerfasserIn]
Osawa, Kosuke [VerfasserIn]
Iwamoto, Ryuta [VerfasserIn]
Murata, Shogo [VerfasserIn]
Mushino, Toshiki [VerfasserIn]
Murata, Shin-Ichi [VerfasserIn]
Araki, Shin-Ichi [VerfasserIn]
Fujii, Takao [VerfasserIn]
Sonoki, Takashi [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

BKL:

44.86$jHämatologie

Themen:

COVID-19
Cytokine storm
Interleukin-6
TAFRO syndrome

Anmerkungen:

© Japanese Society of Hematology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s12185-023-03589-9

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2144948089

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