All-optical optoacoustic micro-tomography in reflection mode
Abstract High-resolution optoacoustic imaging at depths beyond the optical diffusion limit is conventionally performed using a microscopy setup where a strongly focused ultrasound transducer samples the image object point-by-point. Although recent advancements in miniaturized ultrasound detectors enables one to achieve microscopic resolution with an unfocused detector in a tomographic configuration, such an approach requires illuminating the entire object, leading to an inefficient use of the optical power, and imposing a trans-illumination configuration that is limited to thin objects. We developed an optoacoustic micro-tomography system in an epi-illumination configuration, in which the illumination is scanned with the detector. The system is demonstrated in phantoms for imaging depths of up to 5 mm and in vivo for imaging the vasculature of a mouse ear. Although image-formation in optoacoustic tomography generally requires static illumination, our numerical simulations and experimental measurements show that this requirement is relaxed in practice due to light diffusion, which homogenizes the fluence in deep tissue layers..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
|---|---|
| Enthalten in: |
Biomedical engineering letters - 13(2023), 3 vom: 19. Apr., Seite 475-483 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Harary, Tamar [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| BKL: | |
|---|---|
| Themen: |
Imaging techniques |
| Anmerkungen: |
© Korean Society of Medical and Biological Engineering 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
|---|
| doi: |
10.1007/s13534-023-00278-8 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC2144739188 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | OLC2144739188 | ||
| 003 | DE-627 | ||
| 005 | 20240118100626.0 | ||
| 007 | tu | ||
| 008 | 240118s2023 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s13534-023-00278-8 |2 doi | |
| 035 | |a (DE-627)OLC2144739188 | ||
| 035 | |a (DE-He213)s13534-023-00278-8-p | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |a 670 |q VZ |
| 082 | 0 | 4 | |a 620 |a 610 |q VZ |
| 084 | |a 44.09 |2 bkl | ||
| 100 | 1 | |a Harary, Tamar |e verfasserin |0 (orcid)0000-0003-1386-4863 |4 aut | |
| 245 | 1 | 0 | |a All-optical optoacoustic micro-tomography in reflection mode |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a © Korean Society of Medical and Biological Engineering 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. | ||
| 520 | |a Abstract High-resolution optoacoustic imaging at depths beyond the optical diffusion limit is conventionally performed using a microscopy setup where a strongly focused ultrasound transducer samples the image object point-by-point. Although recent advancements in miniaturized ultrasound detectors enables one to achieve microscopic resolution with an unfocused detector in a tomographic configuration, such an approach requires illuminating the entire object, leading to an inefficient use of the optical power, and imposing a trans-illumination configuration that is limited to thin objects. We developed an optoacoustic micro-tomography system in an epi-illumination configuration, in which the illumination is scanned with the detector. The system is demonstrated in phantoms for imaging depths of up to 5 mm and in vivo for imaging the vasculature of a mouse ear. Although image-formation in optoacoustic tomography generally requires static illumination, our numerical simulations and experimental measurements show that this requirement is relaxed in practice due to light diffusion, which homogenizes the fluence in deep tissue layers. | ||
| 650 | 4 | |a Imaging techniques | |
| 650 | 4 | |a Medical and biological imaging | |
| 650 | 4 | |a Optoacoustic tomography | |
| 650 | 4 | |a Photoacoustic imaging | |
| 700 | 1 | |a Hazan, Yoav |4 aut | |
| 700 | 1 | |a Rosenthal, Amir |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biomedical engineering letters |d The Korean Society of Medical and Biological Engineering, 2011 |g 13(2023), 3 vom: 19. Apr., Seite 475-483 |w (DE-627)767568613 |w (DE-600)2732594-5 |w (DE-576)39343558X |x 2093-9868 |7 nnns |
| 773 | 1 | 8 | |g volume:13 |g year:2023 |g number:3 |g day:19 |g month:04 |g pages:475-483 |
| 856 | 4 | 1 | |u https://doi.org/10.1007/s13534-023-00278-8 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 936 | b | k | |a 44.09 |q VZ |
| 951 | |a AR | ||
| 952 | |d 13 |j 2023 |e 3 |b 19 |c 04 |h 475-483 | ||