Redox signaling in impaired cascades of wound healing: promising approach

Abstract In the aging communities, wound healing management is a quite remarkable problem especially in elderly individuals. The optimal level of healing of wounds developed spontaneously or due to surgery is of critical importance in order to prevent the negative effects that may occur due to delayed healing (for example, organ or system damage caused by infections that may develop in the wound area). The deteriorated subcellular redox signaling is considered to be as the main factor in the chronicity of wounds. The pivotal role of mitochondria in redox regulation reveals the importance of modulation of redox signaling pathways in senescent cells. Secretory factors released upon the acquisition of senescence-associated secretory phenotype (SASP) function in a paracrine manner to disseminate impaired tissue redox status by affecting the redox metabolome of nearby cells, which could promote age-related pro-inflammatory pathologies. Evaluating the wound-site redox regulation in impaired redox signaling pathways may help prevent the formation of chronic wounds and the development of long-term complications of the wounds, especially in the elderly. Using the redox modulatory pharmacologically active substances targeting the senescent cells in chronic wound areas hopefully opens a new avenue in wound management. As the signaling mechanisms of wound healing and its relationship with advanced age become more clearly understood, many promising therapeutic approaches and redox modulator substances are coming into clinical view for the management of chronic wounds..

Medienart:

E-Artikel

Erscheinungsjahr:

2023

Erschienen:

2023

Enthalten in:

Zur Gesamtaufnahme - volume:50

Enthalten in:

Molecular biology reports - 50(2023), 8 vom: 21. Juni, Seite 6927-6936

Sprache:

Englisch

Beteiligte Personen:

Atayik, Mehmet Can [VerfasserIn]
Çakatay, Ufuk [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

BKL:

42.13$jMolekularbiologie

Themen:

Aging
Chronic wounds
Redox signaling
Senescence-associated secretory phenotype
Therapeutic approaches
Wound healing

Anmerkungen:

© The Author(s), under exclusive licence to Springer Nature B.V. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s11033-023-08589-w

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2144710635

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