Estimation of the physiologic ability and surgical stress scoring system as a useful predictor of postoperative recurrence in patients with stage II colorectal cancer: a multicenter study
Purpose We determined the usefulness of the estimation of physiologic ability and surgical stress (E-PASS), initially reported as a predictive factor for postoperative morbidity and mortality, as a prognostic indicator in stage II colorectal cancer (CRC). Methods Overall, 739 patients who underwent proctocolectomy for CRC at Tottori University Hospital and affiliated hospitals and histologically diagnosed with stage II CRC were included in the current study. Results A receiver operating characteristic (ROC) analysis of the five-year recurrence-free survival indicated that the comprehensive risk score (CRS) of E-PASS predicted postoperative recurrence. A multivariate analysis revealed that the presence of preoperative perforation, T4, v ≥ 2, and $ CRS^{High} $ (≥ 0.2267) were independent predictors of postoperative recurrence. Patients were assigned a score using these factors, as follows: the presence of perforation = 1, the absence of preoperative perforation = 0, T4 = 1, T3 = 0, v2/3 = 1, v0/1 = 0, $ CRS^{High} $ = 1, and $ CRS^{Low} $ = 0 (total score: 0–4). Accordingly, the respective 5-year relapse-free survival rates were 91.0%, 83.6%, 70.3%, and 52.0% among those with scores of 0, 1, 2, and both 3 and 4 (P < 0.001). Conclusions The CRS predicts postoperative recurrence in patients with stage II CRC..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
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| Enthalten in: |
Surgery today - 53(2023), 8 vom: 15. Feb., Seite 949-956 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tanio, Akimitsu [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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© The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| doi: |
10.1007/s00595-023-02656-2 |
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OLC2144678871 |
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| 520 | |a Purpose We determined the usefulness of the estimation of physiologic ability and surgical stress (E-PASS), initially reported as a predictive factor for postoperative morbidity and mortality, as a prognostic indicator in stage II colorectal cancer (CRC). Methods Overall, 739 patients who underwent proctocolectomy for CRC at Tottori University Hospital and affiliated hospitals and histologically diagnosed with stage II CRC were included in the current study. Results A receiver operating characteristic (ROC) analysis of the five-year recurrence-free survival indicated that the comprehensive risk score (CRS) of E-PASS predicted postoperative recurrence. A multivariate analysis revealed that the presence of preoperative perforation, T4, v ≥ 2, and $ CRS^{High} $ (≥ 0.2267) were independent predictors of postoperative recurrence. Patients were assigned a score using these factors, as follows: the presence of perforation = 1, the absence of preoperative perforation = 0, T4 = 1, T3 = 0, v2/3 = 1, v0/1 = 0, $ CRS^{High} $ = 1, and $ CRS^{Low} $ = 0 (total score: 0–4). Accordingly, the respective 5-year relapse-free survival rates were 91.0%, 83.6%, 70.3%, and 52.0% among those with scores of 0, 1, 2, and both 3 and 4 (P < 0.001). Conclusions The CRS predicts postoperative recurrence in patients with stage II CRC. | ||
| 650 | 4 | |a Colorectal cancer | |
| 650 | 4 | |a E-PASS | |
| 650 | 4 | |a Recurrence | |
| 700 | 1 | |a Saito, Hiroaki |4 aut | |
| 700 | 1 | |a Hara, Kazushi |4 aut | |
| 700 | 1 | |a Sugezawa, Ken |4 aut | |
| 700 | 1 | |a Uejima, Chihiro |4 aut | |
| 700 | 1 | |a Kihara, Kyoichi |4 aut | |
| 700 | 1 | |a Tatebe, Shigeru |4 aut | |
| 700 | 1 | |a Kurisu, Yasuro |4 aut | |
| 700 | 1 | |a Shibata, Shunsuke |4 aut | |
| 700 | 1 | |a Yamamoto, Toshio |4 aut | |
| 700 | 1 | |a Nishie, Hiroshi |4 aut | |
| 700 | 1 | |a Shiota, Setsujo |4 aut | |
| 700 | 1 | |a Naka, Takuji |4 aut | |
| 700 | 1 | |a Sugamura, Kenji |4 aut | |
| 700 | 1 | |a Katano, Kuniyuki |4 aut | |
| 700 | 1 | |a Yamamoto, Manabu |4 aut | |
| 700 | 1 | |a Fujiwara, Yoshiyuki |4 aut | |
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