Determinants of Embryo Implantation: Roles of the Endometrium and Embryo in Implantation Success
Abstract Both uterine endometrium and embryo contribute to implantation success. However, their relative role in the implantation success is still a matter for debate, as are the roles of endometrial receptivity analysis (ERA), endometrial scratch (ES), endometrial microbiome, and intrauterine or intravenous measures that are currently advocated to improve the implantation success. There is insufficient evidence to suggest that the endometrium is more important than the embryo in determining the implantation success and the utility of these measures, especially when euploid embryos are transferred is limited. Although embryo implantation on epithelium other than the endometrium is a very rare event, evidence suggests that embryo implantation and growth is not limited to the endometrium alone. Embryos can implant and develop to result in livebirths on epithelium that lacks the typical endometrial development present at implantation. Currently, the role of embryo euploidy in implantation success is underappreciated. At a minimum, it is the author’s opinion that until robust, definitive studies are conducted that demonstrate benefit, reproductive endocrinologists and infertility specialist should be prudent in the way they counsel patients about the utility of ERA, ES, and other measures in improving implantation success..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Reproductive sciences - 30(2023), 8 vom: 29. März, Seite 2339-2348 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Awonuga, Awoniyi O. [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Advanced extrauterine pregnancy |
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| Anmerkungen: |
© The Author(s), under exclusive licence to Society for Reproductive Investigation 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| doi: |
10.1007/s43032-023-01224-w |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
OLC214454493X |
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| 520 | |a Abstract Both uterine endometrium and embryo contribute to implantation success. However, their relative role in the implantation success is still a matter for debate, as are the roles of endometrial receptivity analysis (ERA), endometrial scratch (ES), endometrial microbiome, and intrauterine or intravenous measures that are currently advocated to improve the implantation success. There is insufficient evidence to suggest that the endometrium is more important than the embryo in determining the implantation success and the utility of these measures, especially when euploid embryos are transferred is limited. Although embryo implantation on epithelium other than the endometrium is a very rare event, evidence suggests that embryo implantation and growth is not limited to the endometrium alone. Embryos can implant and develop to result in livebirths on epithelium that lacks the typical endometrial development present at implantation. Currently, the role of embryo euploidy in implantation success is underappreciated. At a minimum, it is the author’s opinion that until robust, definitive studies are conducted that demonstrate benefit, reproductive endocrinologists and infertility specialist should be prudent in the way they counsel patients about the utility of ERA, ES, and other measures in improving implantation success. | ||
| 650 | 4 | |a Endometrium | |
| 650 | 4 | |a Embryo | |
| 650 | 4 | |a Ectopic pregnancy | |
| 650 | 4 | |a Advanced extrauterine pregnancy | |
| 650 | 4 | |a Livebirth | |
| 700 | 1 | |a Camp, Olivia G. |4 aut | |
| 700 | 1 | |a Abu-Soud, Husam M. |4 aut | |
| 700 | 1 | |a Rappolee, Daniel A. |4 aut | |
| 700 | 1 | |a Puscheck, Elizabeth E. |4 aut | |
| 700 | 1 | |a Diamond, Michael P. |4 aut | |
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