Details der Publikation - Refractory alopecia in lupus treated with tofacitinib

Refractory alopecia in lupus treated with tofacitinib — a case-based review

Abstract One of the common cutaneous symptoms of systemic lupus erythematosus (SLE) that may have major psychosocial effects in a female is diffuse alopecia. Although Janus kinase inhibitors have shown encouraging results in the treatment of SLE and of alopecia areata in recent studies, tofacitinib in treating refractory alopecia caused by SLE has been rarely documented. The Janus kinases (JAKs) are intracellular tyrosine kinases that play a significant role in the pathophysiology of SLE by participating in a wide range of inflammatory cascades. Here, we reported a 33-year-old SLE patient with long standing (3 years) refractory alopecia who took tofacitinib and observed a substantial increase in hair growth. This was sustained at 2-years follow-up even after tapering off glucocorticoids completely. In addition, we reviewed the literature to look for further evidence to support the use of JAK inhibitors for alopecia in SLE..

Medienart:	E-Artikel

Erscheinungsjahr:	2023
Erschienen:	2023

Enthalten in:	Zur Gesamtaufnahme - volume:42
Enthalten in:	Clinical rheumatology - 42(2023), 8 vom: 15. Mai, Seite 2237-2241

Sprache:	Englisch

Beteiligte Personen:	Sarkar, Rajdeep [VerfasserIn] MV, Prakashini [VerfasserIn] Hinduja, Naga [VerfasserIn] Sethy, Mitanjali [VerfasserIn] Kar, Hemanta [VerfasserIn] Ahmed, Sakir [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	Diffuse non-scarring alopecia Hair regrowth Janus kinase inhibitor Systemic lupus erythematosus Tofacitinib

Anmerkungen:	© The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR) 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:	10.1007/s10067-023-06632-6

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2144444242

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520			\|a Abstract One of the common cutaneous symptoms of systemic lupus erythematosus (SLE) that may have major psychosocial effects in a female is diffuse alopecia. Although Janus kinase inhibitors have shown encouraging results in the treatment of SLE and of alopecia areata in recent studies, tofacitinib in treating refractory alopecia caused by SLE has been rarely documented. The Janus kinases (JAKs) are intracellular tyrosine kinases that play a significant role in the pathophysiology of SLE by participating in a wide range of inflammatory cascades. Here, we reported a 33-year-old SLE patient with long standing (3 years) refractory alopecia who took tofacitinib and observed a substantial increase in hair growth. This was sustained at 2-years follow-up even after tapering off glucocorticoids completely. In addition, we reviewed the literature to look for further evidence to support the use of JAK inhibitors for alopecia in SLE.
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Refractory alopecia in lupus treated with tofacitinib — a case-based review

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