Benchmarks and Geographic Differences in Gallbladder Cancer Surgery: An International Multicenter Study

Background High-quality surgery plays a central role in the delivery of excellent oncologic care. Benchmark values indicate the best achievable results. We aimed to define benchmark values for gallbladder cancer (GBC) surgery across an international population. Patients and Methods This study included consecutive patients with GBC who underwent curative-intent surgery during 2000–2021 at 13 centers, across seven countries and four continents. Patients operated on at high-volume centers without the need for vascular and/or bile duct reconstruction and without significant comorbidities were chosen as the benchmark group. Results Of 906 patients who underwent curative-intent GBC surgery during the study period, 245 (27%) were included in the benchmark group. These were predominantly women (n = 174, 71%) and had a median age of 64 years (interquartile range 57–70 years). In the benchmark group, 50 patients (20%) experienced complications within 90 days after surgery, with 20 patients (8%) developing major complications (Clavien–Dindo grade ≥ IIIa). Median length of postoperative hospital stay was 6 days (interquartile range 4–8 days). Benchmark values included ≥ 4 lymph nodes retrieved, estimated intraoperative blood loss ≤ 350 mL, perioperative blood transfusion rate ≤ 13%, operative time ≤ 332 min, length of hospital stay ≤ 8 days, R1 margin rate ≤ 7%, complication rate ≤ 22%, and rate of grade ≥ IIIa complications ≤ 11%. Conclusions Surgery for GBC remains associated with significant morbidity. The availability of benchmark values may facilitate comparisons in future analyses among GBC patients, GBC surgical approaches, and centers performing GBC surgery..

Medienart:

E-Artikel

Erscheinungsjahr:

2023

Erschienen:

2023

Enthalten in:

Zur Gesamtaufnahme - volume:30

Enthalten in:

Annals of surgical oncology - 30(2023), 8 vom: 06. Mai, Seite 4904-4911

Sprache:

Englisch

Beteiligte Personen:

Vega, Eduardo A. [VerfasserIn]
Newhook, Timothy E. [VerfasserIn]
Mellado, Sebastian [VerfasserIn]
Ruzzenente, Andrea [VerfasserIn]
Okuno, Masayuki [VerfasserIn]
De Bellis, Mario [VerfasserIn]
Panettieri, Elena [VerfasserIn]
Ahmad, M. Usman [VerfasserIn]
Merlo, Ignacio [VerfasserIn]
Rojas, Jesus [VerfasserIn]
De Rose, Agostino M. [VerfasserIn]
Nishino, Hiroto [VerfasserIn]
Sinnamon, Andrew J. [VerfasserIn]
Donadon, Matteo [VerfasserIn]
Hauger, Marit S. [VerfasserIn]
Guevara, Oscar A. [VerfasserIn]
Munoz, Cesar [VerfasserIn]
Denbo, Jason W. [VerfasserIn]
Chun, Yun Shin [VerfasserIn]
Tran Cao, Hop S. [VerfasserIn]
Sanchez Claria, Rodrigo [VerfasserIn]
Tzeng, Ching-Wei D. [VerfasserIn]
De Aretxabala, Xabier [VerfasserIn]
Vivanco, Marcelo [VerfasserIn]
Brudvik, Kristoffer W. [VerfasserIn]
Seo, Satoru [VerfasserIn]
Pekolj, Juan [VerfasserIn]
Poultsides, George A. [VerfasserIn]
Torzilli, Guido [VerfasserIn]
Giuliante, Felice [VerfasserIn]
Anaya, Daniel A. [VerfasserIn]
Guglielmi, Alfredo [VerfasserIn]
Vinuela, Eduardo [VerfasserIn]
Vauthey, Jean-Nicolas [VerfasserIn]

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Anmerkungen:

© Society of Surgical Oncology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1245/s10434-023-13531-2

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2144290210

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