Comparative efficacy of different treatments for menstrual migraine: a systematic review and network meta-analysis

Background Menstrual migraine is a subtype of migraine disease that is typically more disabling, longer-lasting, and more challenging to treat. The purpose of this network meta-analysis (NMA) is to compare the relative efficacy of treatments for menstrual migraine. Methods We systematically searched databases, including PubMed, EMBASE, and Cochrane, and included all eligible randomized controlled trials in the study. We conducted the statistical analysis using Stata version 14.0, based on the frequentist framework. We used the Cochrane Risk of Bias tool for randomized trials version 2 (RoB2) to assess the risk of bias of the included studies. Results This network meta-analysis included 14 randomized controlled trials with 4601 patients. For short-term prophylaxis, frovatriptan 2.5 mg twice daily had the highest probability of effectiveness [OR = 1.87 (95% CI: 1.48 to 2.38)] compared to placebo. For acute treatment, the results showed that sumatriptan 100 mg [OR = 4.32 (95% CI: 2.95 to 6.34)] was the most effective treatment compared to placebo. Conclusions These findings suggest that frovatriptan 2.5 mg twice daily was best for short-term prevention, sumatriptan 100 mg were best for acute treatment. More high-quality randomized trials are required to determine the most effective treatment..

Medienart:

E-Artikel

Erscheinungsjahr:

2023

Erschienen:

2023

Enthalten in:

Zur Gesamtaufnahme - volume:24

Enthalten in:

The journal of headache and pain - 24(2023), 1 vom: 03. Juli

Sprache:

Englisch

Beteiligte Personen:

Zhang, Han [VerfasserIn]
Qi, Jian-Zhi [VerfasserIn]
Zhang, Zhi-Hua [VerfasserIn]

Links:

Volltext [kostenfrei]

BKL:

44.90 / Neurologie / Neurologie

Themen:

Menstrual migraine
Migraine disease
Network meta-analysis
Randomized controlled trials
Systematic review

Anmerkungen:

© The Author(s) 2023

doi:

10.1186/s10194-023-01625-x

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2144273278