Details der Publikation - HPV-associated cancers: insights into the mechanistic scenario and latest updates

HPV-associated cancers: insights into the mechanistic scenario and latest updates

Abstract Cancer and related diseases are the second leading cause of death worldwide. The human papillomavirus (HPV) is an infectious agent that can be spread mainly through sexual contact and has been linked to several malignancies in both sexes. HPV is linked to almost all cases of cervical cancer. It is also linked to many head and neck cancer (HNC) cases, especially oropharyngeal cancer. Also, some HPV-related cancers, like vaginal, vulvar, penile, and anal cancers, are related to the anogenital area. Over the past few decades, testing for and preventing cervical cancer has improved, but anogenital cancers are still harder to confirm. HPV16 and HPV18 have been extensively researched due to their significant carcinogenic potential. The products of two early viral genes, E6 and E7, have been identified as playing crucial roles in cellular transformation, as emphasized by biological investigations. The complete characterization of numerous mechanisms employed by E6 and E7 in undermining the regulation of essential cellular processes has significantly contributed to our comprehension of HPV-induced cancer progression. This review focuses on the various types of cancers caused by HPV infection and also sheds light on the signaling cascades involved in the same..

Medienart:	E-Artikel

Erscheinungsjahr:	2023
Erschienen:	2023

Enthalten in:	Zur Gesamtaufnahme - volume:40
Enthalten in:	Medical oncology - 40(2023), 8 vom: 26. Juni

Sprache:	Englisch

Beteiligte Personen:	Mukherjee, Anirban Goutam [VerfasserIn] Ramesh Wanjari, Uddesh [VerfasserIn] Valsala Gopalakrishnan, Abilash [VerfasserIn] Jayaraj, Rama [VerfasserIn] Katturajan, Ramkumar [VerfasserIn] Kannampuzha, Sandra [VerfasserIn] Murali, Reshma [VerfasserIn] Namachivayam, Arunraj [VerfasserIn] Evan Prince, Sabina [VerfasserIn] Vellingiri, Balachandar [VerfasserIn] Dey, Abhijit [VerfasserIn] Renu, Kaviyarasi [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	Cancers HPV infection Immunology Vaccines

Anmerkungen:	© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:	10.1007/s12032-023-02085-8

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2144143528

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520			\|a Abstract Cancer and related diseases are the second leading cause of death worldwide. The human papillomavirus (HPV) is an infectious agent that can be spread mainly through sexual contact and has been linked to several malignancies in both sexes. HPV is linked to almost all cases of cervical cancer. It is also linked to many head and neck cancer (HNC) cases, especially oropharyngeal cancer. Also, some HPV-related cancers, like vaginal, vulvar, penile, and anal cancers, are related to the anogenital area. Over the past few decades, testing for and preventing cervical cancer has improved, but anogenital cancers are still harder to confirm. HPV16 and HPV18 have been extensively researched due to their significant carcinogenic potential. The products of two early viral genes, E6 and E7, have been identified as playing crucial roles in cellular transformation, as emphasized by biological investigations. The complete characterization of numerous mechanisms employed by E6 and E7 in undermining the regulation of essential cellular processes has significantly contributed to our comprehension of HPV-induced cancer progression. This review focuses on the various types of cancers caused by HPV infection and also sheds light on the signaling cascades involved in the same.
650		4	\|a Cancers
650		4	\|a HPV infection
650		4	\|a Immunology
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HPV-associated cancers: insights into the mechanistic scenario and latest updates

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