Details der Publikation - Exploring the Complex Relationship Between Microbiota and Systemic Lupus Erythematosus

Exploring the Complex Relationship Between Microbiota and Systemic Lupus Erythematosus

Purpose of Review Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by various autoantibodies and multi-organ. Microbiota dysbiosis in the gut, skin, oral, and other surfaces has a significant impact on SLE development. This article summarizes relevant research and provides new microbiome-related strategies for exploring the mechanisms and treating patients with SLE. Recent Findings SLE patients have disruptions in multiple microbiomes, with the gut microbiota (bacteria, viruses, and fungi) and their metabolites being the most thoroughly researched. This dysbiosis can promote SLE progression through mechanisms such as the leaky gut, molecular mimicry, and epigenetic regulation. Summary Notwithstanding study constraints on the relationship between microbiota and SLE, specific interventions targeting the gut microbiota, such as probiotics, dietary management, and fecal microbiota transplantation, have emerged as promising SLE therapeutics..

Medienart:	E-Artikel

Erscheinungsjahr:	2023
Erschienen:	2023

Enthalten in:	Zur Gesamtaufnahme - volume:25
Enthalten in:	Current rheumatology reports - 25(2023), 6 vom: 21. Apr., Seite 107-116

Sprache:	Englisch

Beteiligte Personen:	Lei, Yu [VerfasserIn] Liu, Qianmei [VerfasserIn] Li, Qilin [VerfasserIn] Zhao, Cheng [VerfasserIn] Zhao, Ming [VerfasserIn] Lu, Qianjin [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.83$jRheumatologie$jOrthopädie
Themen:	Autoimmunity Dysbiosis Microbiota Systemic lupus erythematosus

Anmerkungen:	© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:	10.1007/s11926-023-01102-z

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2143923937

Internformat


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Exploring the Complex Relationship Between Microbiota and Systemic Lupus Erythematosus

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