Health-related quality of life and use of medication with anticholinergic activity in patients with multiple myeloma

Purpose Verify the association between anticholinergic burden and health-related quality of life of patients with multiple myeloma. Methods Cross-sectional study with multiple myeloma outpatient from a state capital city in southeastern Brazil. Sociodemographic, clinical, and pharmacotherapeutic variables were collected by interview. Clinical data were complemented by medical records. Drugs with anticholinergic activity were identified with Brazilian Anticholinergic Activity Drug Scale. Health-related quality of life scores were obtained using QLQ-C30 and QLQ-MY20 instruments. Mann-Whitney was used to compare the median of the health-related quality of life scale scores and the independent variables. Multivariate linear regression was performed to verify the association between independent variables and health-related quality of life scores. Results Two hundred thirteen patients were included, 56.3% had multi-morbidities, and 71.8% used polypharmacy. In all health-related quality of life domains, there were differences between the medians of the polypharmacy variable. A significant difference was identified between the ACh burden and QLQ-C30 and QLQ-MY20 scores. Linear regression identified an association between the use of drugs with anticholinergic activity and the reduction of global status scores (QLQ-C30), functional scale (QLQ-C30), body image (QLQ-MY20), and future perspective (QLQ-MY20). Drugs with anticholinergic activity were associated with increased symptom scores (QLQ-C30 and QLQ-MY20). Polypharmacy was associated with reduction of functioning score and increase of symptom score (QLQ-C30). Conclusion Anticholinergic burden in MM patients is associated with lower scores in quality of life domains: global health and symptoms (QLQ-C30) and functional (QLQ-C30 and QLQ-MY20). The presence of polypharmacy is also associated with lower scores for functional scales and symptom scales (QLQ-C30)..

Medienart:

E-Artikel

Erscheinungsjahr:

2023

Erschienen:

2023

Enthalten in:

Zur Gesamtaufnahme - volume:31

Enthalten in:

Supportive care in cancer - 31(2023), 7 vom: 06. Juni

Sprache:

Englisch

Beteiligte Personen:

de Lima, Mariana Sampaio Rodrigues [VerfasserIn]
de Pádua, Cristiane Aparecida Menezes [VerfasserIn]
de Miranda Drummond, Paula Lana [VerfasserIn]
Silveira, Lívia Pena [VerfasserIn]
Malta, Jéssica Soares [VerfasserIn]
dos Santos, Roberta Márcia Marques [VerfasserIn]
Reis, Adriano Max Moreira [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

Themen:

Adult
Aged
Cholinergic antagonists
Health-related quality of life
Multiple myeloma

RVK:

RVK Klassifikation

Anmerkungen:

© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s00520-023-07835-y

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2143717717

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