Positive fluid balance and diuretic therapy are associated with mechanical ventilation and mortality in preterm neonates in the first fourteen postnatal days

Background Fluid overload leads to poor neonatal outcomes. Diuretics may lower the rates of mechanical ventilation (MV) and mortality in neonates with fluid overload. Methods This is a retrospective study of preterm neonates ≤ 36 weeks of gestational age (GA) in the first 14 postnatal days in a level IV NICU in 2014–2020. We evaluated the epidemiology of fluid balance in the first 14 postnatal days and its association with MV and mortality and studied the association of diuretics with fluid balance, MV, and mortality. Results In 1383 included neonates, the overall median lowest and peak fluid balances were − 7.8% (IQR: − 11.7, − 4.6) and 8% (3, 16) on days 3 (2, 5) and 13 (5, 14), respectively. Fluid balance distribution varied significantly by GA. Peak fluid balance of ≥ 10% was associated with increased odds of MV on days 7 and 14 with highest odds ratios (OR) of MV in neonates with fluid balance ≥ 15%. Peak fluid balance of ≥ 15% was associated with the greatest odds of mortality. Diuretics were used more frequently in neonates with younger GA, smaller birthweight, positive fluid balance, and those on MV. Conclusions Positive fluid balance negatively impacts pulmonary status. The odds of MV and death increase significantly as peak fluid balance percentage increases in all GA groups. The impact of diuretics on MV and death in preterm neonates needs further evaluation. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information.

Medienart:

E-Artikel

Erscheinungsjahr:

2023

Erschienen:

2023

Enthalten in:

Zur Gesamtaufnahme - volume:38

Enthalten in:

Pediatric nephrology - 38(2023), 7 vom: 04. Jan., Seite 2243-2253

Sprache:

Englisch

Beteiligte Personen:

Wright, Mariah L. [VerfasserIn]
Klamer, Brett G. [VerfasserIn]
Bonachea, Elizabeth [VerfasserIn]
Spencer, John D. [VerfasserIn]
Slaughter, Jonathan L. [VerfasserIn]
Mohamed, Tahagod H. [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

Themen:

Diuretics
Fluid balance
Fluid overload
Mechanical ventilation
Neonates

Anmerkungen:

© The Author(s), under exclusive licence to International Pediatric Nephrology Association 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s00467-022-05861-2

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2143632401

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