Low-Dose Initiation of Buprenorphine: A Narrative Review

Purpose of Review Opioid use disorder (OUD) is a chronic disorder in which a person loses control over the use of opioids, develops a compulsive behavior, and defends the use despite knowing the negative consequences. There are numerous treatments for OUD, including buprenorphine. Since it is displacing a full agonist opioid, precipitated withdrawal can occur with standard inductions involving buprenorphine. Recent Findings Case reports have noted success with a low-dose initiation of buprenorphine, which is different from typical protocols, relatively limited by adverse effects when patients were recently administered full agonists. A cohort investigation studied the use of a transdermal patch as part of the protocol, which was fairly well tolerated. Summary While ongoing research is being conducted on this topic, recent case studies and smaller cohort studies have demonstrated the feasibility of a trial to treat OUD with low-dose initiation of buprenorphine..

Medienart:

E-Artikel

Erscheinungsjahr:

2023

Erschienen:

2023

Enthalten in:

Zur Gesamtaufnahme - volume:27

Enthalten in:

Current pain and headache reports - 27(2023), 7 vom: 21. Apr., Seite 175-181

Sprache:

Englisch

Beteiligte Personen:

Edinoff, Amber N. [VerfasserIn]
Fahmy, Omar H. [VerfasserIn]
Spillers, Noah J. [VerfasserIn]
Zaheri, Alexa R. [VerfasserIn]
Jackson, Eric D. [VerfasserIn]
De Witt, Audrey J. [VerfasserIn]
Wenger, Danielle M. [VerfasserIn]
Cornett, Elyse M. [VerfasserIn]
Skidmore, Kimberly L. [VerfasserIn]
Kaye, Adam M. [VerfasserIn]
Kaye, Alan D. [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

BKL:

44.90$jNeurologie

Themen:

Addiction treatment
Buprenorphine
Fentanyl
Lose dose
Opioid use disorder
Withdrawal

Anmerkungen:

© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s11916-023-01116-3

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2143615108

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