Details der Publikation - Effect of anti-resistance exercise intervention on sarcopenia in hemodialysis patients under nanofiber-based composite membrane

Effect of anti-resistance exercise intervention on sarcopenia in hemodialysis patients under nanofiber-based composite membrane

Abstract To explore the intervention effect of anti-resistance exercise on sarcopenia in hemodialysis patients, the polyvinyl alcohol/polyacrylonitrile nanofiber-based composite membrane (PVA/PAN TFNC) was prepared in this study under optimized conditions, which was compared with traditional polysulfone (PSf) membrane for dialysis performance test. Then, a controlled experiment was used in the hemodialysis treatment of 46 maintenance hemodialysis (MHD) patients with sarcopenia detected in Chengdu First People’s Hospital. The patients from the control group should have 12 weeks of regular exercise, while the intervention group received 12 weeks of anti-resistance exercise intervention. It was found that the optimized PVA/PAN TFNC membrane had good dialysis performance (urea clearance rate of 83.4%, lysozyme clearance rate of 47.6%, and bovine serum albumin (BSA) retention rate of 98.7%). After anti-resistance exercise intervention, there were statistically marked differences in physical activity status (maximum grip strength and daily pace), nutritional status (serum albumin), dialysis adequacy (Kt/V), and quality of life score between the intervention group and the control group (P < 0.05). In addition, the levels of inflammatory cytokines (interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α) of the intervention group changed obviously before and after intervention, namely anti-resistance exercise intervention in dialysis could improve the micro-inflammatory state. In conclusion, the optimized PVA/PAN TFNC membrane had good dialysis performance. Anti-resistance exercise in dialysis could promote the physical status of MHD patients complicated with sarcopenia, improve the nutritional status, and reduce micro-inflammatory response, thus enhancing the quality of life of patients..

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:13
Enthalten in:	Applied nanoscience - 13(2022), 5 vom: 26. Dez., Seite 3599-3608

Sprache:	Englisch

Beteiligte Personen:	Chen, Tingyu [VerfasserIn] Ye, Liang [VerfasserIn] Yu, Qinsheng [VerfasserIn] Ao, Guangyu [VerfasserIn] Liu, Qiang [VerfasserIn] Zhou, Shulu [VerfasserIn] Zhong, Jian [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	50.94 / Mikrosystemtechnik / Nanotechnologie / Mikrosystemtechnik / Nanotechnologie
Themen:	Anti-resistance exercise Maintenance hemodialysis Nanofiber-based composite membrane Sarcopenia

Anmerkungen:	© Springer Nature Switzerland AG 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:	10.1007/s13204-022-02740-y

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2134687738

Internformat


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520			\|a Abstract To explore the intervention effect of anti-resistance exercise on sarcopenia in hemodialysis patients, the polyvinyl alcohol/polyacrylonitrile nanofiber-based composite membrane (PVA/PAN TFNC) was prepared in this study under optimized conditions, which was compared with traditional polysulfone (PSf) membrane for dialysis performance test. Then, a controlled experiment was used in the hemodialysis treatment of 46 maintenance hemodialysis (MHD) patients with sarcopenia detected in Chengdu First People’s Hospital. The patients from the control group should have 12 weeks of regular exercise, while the intervention group received 12 weeks of anti-resistance exercise intervention. It was found that the optimized PVA/PAN TFNC membrane had good dialysis performance (urea clearance rate of 83.4%, lysozyme clearance rate of 47.6%, and bovine serum albumin (BSA) retention rate of 98.7%). After anti-resistance exercise intervention, there were statistically marked differences in physical activity status (maximum grip strength and daily pace), nutritional status (serum albumin), dialysis adequacy (Kt/V), and quality of life score between the intervention group and the control group (P < 0.05). In addition, the levels of inflammatory cytokines (interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α) of the intervention group changed obviously before and after intervention, namely anti-resistance exercise intervention in dialysis could improve the micro-inflammatory state. In conclusion, the optimized PVA/PAN TFNC membrane had good dialysis performance. Anti-resistance exercise in dialysis could promote the physical status of MHD patients complicated with sarcopenia, improve the nutritional status, and reduce micro-inflammatory response, thus enhancing the quality of life of patients.
650		4	\|a Nanofiber-based composite membrane
650		4	\|a Sarcopenia
650		4	\|a Anti-resistance exercise
650		4	\|a Maintenance hemodialysis
700	1		\|a Ye, Liang \|4 aut
700	1		\|a Yu, Qinsheng \|4 aut
700	1		\|a Ao, Guangyu \|4 aut
700	1		\|a Liu, Qiang \|4 aut
700	1		\|a Zhou, Shulu \|4 aut
700	1		\|a Zhong, Jian \|4 aut
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Effect of anti-resistance exercise intervention on sarcopenia in hemodialysis patients under nanofiber-based composite membrane

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