Details der Publikation - The role of HPV status in patients with overlapping grey zone cancer in oral cavity and oropharynx

The role of HPV status in patients with overlapping grey zone cancer in oral cavity and oropharynx

Purpose We aimed to explore the clinicodemographic characteristics and prognosis of grey zone squamous cell cancer (GZSCC) located in the overlapping or ambiguous area of oral cavity and oropharynx and to identify valuable factors that would improve its differential diagnosis and prognosis. Methods Information of GZSCC patients in the Surveillance, Epidemiology, and End Results (SEER) database were compared to patients with oral cavity (OCSCC) and oropharyngeal (OPSCC) squamous cell carcinomas with corresponding HPV status, respectively. Kaplan–Meier method with log-rank test and multivariate Cox regression analysis were applied to assess associations between clinical characteristics and overall survival (OS). A predictive model integrating age, gender, marital status, HPV status and staging variables was conducted to classify GZSCC patients into three risk groups and verified internally by tenfold cross validation. Results A total of 3318 GZSCC, 10792 OPSCC and 6656 OCSCC patients were identified. HPV-positive GZSCC patients had the best 5-year OS as HPV-positive OPSCC (81% vs. 82%). However, the 5-year OS of HPV-negative/unknown GZSCC (43%/42%) were the worst among all groups, indicating that HPV status and the overlapping nature of tumors were valuable prognostic predictors in GZSCC patients. Compared with the strategy of dividing GZSCC into two groups by HPV status, the predictive model integrating more variables could additionally identify a unique high-risk GZSCC group with the lowest OS rate. Conclusions GZSCC patients had distinct clinical characteristics and prognosis compared with OPSCC and OCSCC, integrating HPV status and other clinical factors could help distinguish GZSCC and predict their prognosis..

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:280
Enthalten in:	European archives of oto-rhino-laryngology and head & neck - 280(2022), 3 vom: 08. Nov., Seite 1455-1465

Sprache:	Englisch

Beteiligte Personen:	Song, Yao [VerfasserIn] Cheng, Danni [VerfasserIn] Yi, Xiaowei [VerfasserIn] Rao, Yufang [VerfasserIn] Qiu, Ke [VerfasserIn] Mao, Minzi [VerfasserIn] Pang, Wendu [VerfasserIn] Li, Junhong [VerfasserIn] Zheng, Yongbo [VerfasserIn] Feng, Renyuan [VerfasserIn] Song, Xiaoping [VerfasserIn] Huang, Shaohui [VerfasserIn] Liu, Geoffrey [VerfasserIn] Xu, Wei [VerfasserIn] Zhao, Yu [VerfasserIn] Ren, Jianjun [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.94$jHals-Nasen-Ohrenheilkunde
Themen:	Human papillomavirus Oral cavity Oropharynx Squamous cell carcinoma Survival

Anmerkungen:	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:	10.1007/s00405-022-07713-z

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2133784381

Internformat


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520			\|a Purpose We aimed to explore the clinicodemographic characteristics and prognosis of grey zone squamous cell cancer (GZSCC) located in the overlapping or ambiguous area of oral cavity and oropharynx and to identify valuable factors that would improve its differential diagnosis and prognosis. Methods Information of GZSCC patients in the Surveillance, Epidemiology, and End Results (SEER) database were compared to patients with oral cavity (OCSCC) and oropharyngeal (OPSCC) squamous cell carcinomas with corresponding HPV status, respectively. Kaplan–Meier method with log-rank test and multivariate Cox regression analysis were applied to assess associations between clinical characteristics and overall survival (OS). A predictive model integrating age, gender, marital status, HPV status and staging variables was conducted to classify GZSCC patients into three risk groups and verified internally by tenfold cross validation. Results A total of 3318 GZSCC, 10792 OPSCC and 6656 OCSCC patients were identified. HPV-positive GZSCC patients had the best 5-year OS as HPV-positive OPSCC (81% vs. 82%). However, the 5-year OS of HPV-negative/unknown GZSCC (43%/42%) were the worst among all groups, indicating that HPV status and the overlapping nature of tumors were valuable prognostic predictors in GZSCC patients. Compared with the strategy of dividing GZSCC into two groups by HPV status, the predictive model integrating more variables could additionally identify a unique high-risk GZSCC group with the lowest OS rate. Conclusions GZSCC patients had distinct clinical characteristics and prognosis compared with OPSCC and OCSCC, integrating HPV status and other clinical factors could help distinguish GZSCC and predict their prognosis.
650		4	\|a Oropharynx
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650		4	\|a Squamous cell carcinoma
650		4	\|a Survival
650		4	\|a Human papillomavirus
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700	1		\|a Liu, Geoffrey \|4 aut
700	1		\|a Xu, Wei \|4 aut
700	1		\|a Zhao, Yu \|4 aut
700	1		\|a Ren, Jianjun \|0 (orcid)0000-0002-5938-688X \|4 aut
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The role of HPV status in patients with overlapping grey zone cancer in oral cavity and oropharynx

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