Immunogenic cell death (ICD)-inducers in non-small-cell lung carcinoma (NSCLC): current knowledge and future perspective

Abstract The prevalence of non-small-cell lung cancer (NSCLC) is rising every year all around the world. The interaction between cancer cells and the tumor microenvironment (TME) is a crucial factor in determining the development of human neoplasms. Organellar and cellular stress are induced during immunogenic cell death (ICD), a particularly functional response pattern. ICD is a separate but poorly characterized entity caused by various cancer treatments. The induction of ICD has the potential to change TME and the recruitment of tumor-infiltrating lymphocytes (TILs), and the coupling of ICD-inducers and other therapeutic approaches can have a synergistic role in boosting anticancer impacts. The purpose of this study is to review the studies in the field of NSCLC using ICD-inducers as a treatment strategy or as a combination therapy. This review provide for researches a better view of what has been done so far and the challenges they face in the future..

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:25

Enthalten in:

Clinical and translational oncology - 25(2022), 2 vom: 30. Sept., Seite 316-322

Sprache:

Englisch

Beteiligte Personen:

Kashefizadeh, Alireza [VerfasserIn]
Kazemizadeh, Hossein [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

BKL:

44.81$jOnkologie

Themen:

Immunogenic cell death
Immunotherapy
Lung cancer
NSCLC

Anmerkungen:

© The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO) 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s12094-022-02949-x

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2133537252