Clinical Course and Outcomes in Patients with Left Ventricular Dysfunction Due to Myocardial Infarction After Kawasaki Disease

Abstract Long-term outcomes of patients with left ventricular dysfunction after Kawasaki disease (KD) remain unknown. The clinical course of 37 patients (29 males 8 females) with left ventricular ejection function (LVEF) less than 45% after KD since 1978 was retrospectively investigated. Cardiac events in this study were defined as admissions because of heart failure, fatal ventricular arrhythmias, heart transplantation, and death. Their ages when evaluated ranged from 1 to 70 years (median 35 years). The onset of KD ranged from 2 months to 20 years (median 21 months). All patients had bilateral coronary artery lesions, and multi-vessel occlusion occurred in 31 patients (84%). Previous myocardial infarction (MI) was found in 28 patients (76%). The interval from the onset of acute KD to the initial MI ranged from 15 days to 25 years (median 3 months). Reperfusion therapy was successful in 6 patients (30%), and coronary artery bypass grafting was performed in 23 patients (62%). Non-sustained ventricular tachycardia and fatal ventricular arrhythmias were detected in 11 patients and 22 patients, respectively. There were 15 deaths (41%). The 20-year and 50-year survival rates after KD were 84% (95% CI 67–92) and 54% (34–73), respectively (n = 37). The 30-year cardiac event-free rate after the detection of low LVEF was 42% (95% CI 27–59). The cutoff point of the left ventricular end-diastolic dimension for cardiac events was 65 mm. Patients with low LVEF had fatal ventricular arrhythmias and a worsening of their ischemic cardiomyopathy after 30 years of age and their outcomes were poor..

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:44

Enthalten in:

Pediatric cardiology - 44(2022), 1 vom: 21. Juli, Seite 187-195

Sprache:

Englisch

Beteiligte Personen:

Tsuda, Etsuko [VerfasserIn]
Yamada, Osam [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

Themen:

Fatal ventricular arrhythmia
Kawasaki disease
Left ventricular dysfunction
Left ventricular end-diastolic dimension
Myocardial infarction

RVK:

RVK Klassifikation

Anmerkungen:

© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022

doi:

10.1007/s00246-022-02971-4

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2133444254

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