Details der Publikation - Regulation of artificial supramolecular transmembrane signal transduction by selenium-containing artificial enzyme receptors

Regulation of artificial supramolecular transmembrane signal transduction by selenium-containing artificial enzyme receptors

Abstract Signal transduction across lipid bilayers is of profound importance in biological processes. In biological systems, natural enzymes mediate biochemical effects by binding to substrates and facilitating the conversion of external signals into physiological responses. Sequential transmission of biological signals from one enzyme to the next promotes signal transduction with feedforward and feedback mechanisms. Reconstructing these processes in an artificial system provides potential applications and offers a new way to understand fundamental biological processes in depth. However, the design of artificial signal transduction systems regulated by artificial enzyme receptors in a predictable and intelligent manner remains a challenge. Herein, benefiting from the polarity-regulated characteristics of Se-containing compounds with artificial glutathione peroxidase (GPx) activity, we constructed an artificial transmembrane signaling receptor with a Se-containing GPx-like recognition head group, a membrane-anchoring group, and a pre-enzyme end group. The artificial supramolecular signal transduction system containing such signal transduction receptors extends the range of signaling systems based on enzyme regulation, which provides a new way to study natural signal processes in cells and artificially regulated biological processes..

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:16
Enthalten in:	Nano research - 16(2022), 1 vom: 31. Aug., Seite 964-969

Sprache:	Englisch

Beteiligte Personen:	Liu, Shengda [VerfasserIn] Xing, Yunpeng [VerfasserIn] Yan, Tengfei [VerfasserIn] Li, Yijia [VerfasserIn] Tian, Ruizhen [VerfasserIn] Hou, Jinxing [VerfasserIn] Xu, Jiayun [VerfasserIn] Wang, Tingting [VerfasserIn] Liu, Junqiu [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	Artificial enzyme Selenium-containing glutathione peroxidase (GPx)-like receptors Signal transduction Supramolecular introduction

Anmerkungen:	© Tsinghua University Press 2022

doi:	10.1007/s12274-022-4814-4

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2133382445

Internformat


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520			\|a Abstract Signal transduction across lipid bilayers is of profound importance in biological processes. In biological systems, natural enzymes mediate biochemical effects by binding to substrates and facilitating the conversion of external signals into physiological responses. Sequential transmission of biological signals from one enzyme to the next promotes signal transduction with feedforward and feedback mechanisms. Reconstructing these processes in an artificial system provides potential applications and offers a new way to understand fundamental biological processes in depth. However, the design of artificial signal transduction systems regulated by artificial enzyme receptors in a predictable and intelligent manner remains a challenge. Herein, benefiting from the polarity-regulated characteristics of Se-containing compounds with artificial glutathione peroxidase (GPx) activity, we constructed an artificial transmembrane signaling receptor with a Se-containing GPx-like recognition head group, a membrane-anchoring group, and a pre-enzyme end group. The artificial supramolecular signal transduction system containing such signal transduction receptors extends the range of signaling systems based on enzyme regulation, which provides a new way to study natural signal processes in cells and artificially regulated biological processes.
650		4	\|a signal transduction
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700	1		\|a Li, Yijia \|4 aut
700	1		\|a Tian, Ruizhen \|4 aut
700	1		\|a Hou, Jinxing \|4 aut
700	1		\|a Xu, Jiayun \|4 aut
700	1		\|a Wang, Tingting \|4 aut
700	1		\|a Liu, Junqiu \|4 aut
773	0	8	\|i Enthalten in \|t Nano research \|d Tsinghua University Press, 2008 \|g 16(2022), 1 vom: 31. Aug., Seite 964-969 \|h Online-Ressource \|w (DE-627)57375361X \|w (DE-600)2442216-2 \|w (DE-576)306837110 \|x 1998-0000 \|7 nnns
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Regulation of artificial supramolecular transmembrane signal transduction by selenium-containing artificial enzyme receptors

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