Development of a 3D disposable device for the electrochemical determination of diclofenac in different matrices

Abstract In this work, the development of a disposable electrochemical device (US$ 0.02 per electrode) using a 3D printed support (3Ds) of acrylonitrile butadiene styrene (ABS) insulating filament with a composite material (CM) based on graphite and nail polish, immobilized on the support surface, was described for the electrochemical determination of diclofenac (DCF). The device was compared to the commercial glassy carbon electrode (GCE) and showed superior electroanalytical performance with approximately 1.8-fold higher current density. Additionally, an amperometric method for DCF determination in tap water, synthetic urine, and pharmaceutical formulation samples with the proposed electrode, using a flow injection analysis (FIA-AD) system, was developed. The optimized method presented excellent detectability (LOD = 0.47 µmol $ L^{−1} $), with excellent precision and accuracy (relative standard deviation < 5.6%) and percent recovery from spiked samples ranging from 89 to 106%. In addition, the sensor showed optimal analytical frequency with approximately 108 injections per hour, which demonstrates the potential of this system using the proposed disposable electrode for implementation in routine analysis and quality control with good selectivity and sensitivity..

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:415

Enthalten in:

Analytical and bioanalytical chemistry - 415(2022), 2 vom: 08. Nov., Seite 357-366

Sprache:

Englisch

Beteiligte Personen:

Lisboa, Thalles Pedrosa [VerfasserIn]
de Oliveira, Wallace Burger Veríssimo [VerfasserIn]
de Souza, Cassiano Cunha [VerfasserIn]
Oliveira, Raylla Santos [VerfasserIn]
Matos, Maria Auxiliadora Costa [VerfasserIn]
Matos, Renato Camargo [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

BKL:

35.23$jAnalytische Chemie: Allgemeines

35.71$jBiochemische Methoden

42.03$jMethoden und Techniken der Biologie

Themen:

Anti-inflammatory drug
Composite material
Diclofenac
Disposable electrode
Flow injection analysis

RVK:

RVK Klassifikation

Anmerkungen:

© Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s00216-022-04414-8

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2133267298

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