Outcome of patients with differentiated thyroid cancer treated with empirical radioiodine therapy on the basis of Thyroglobulin Elevation Negative Iodine Scintigraphy (TENIS) syndrome without structural disease: a retrospective cohort study

Background For differentiated thyroid cancer (DTC) patients with thyroglobulin (Tg) elevation and negative iodine scintigraphy (commonly termed "TENIS" syndrome) after thyroidectomy, radioactive iodine (RAI) therapy, and thyroid-stimulating hormone (TSH) suppression therapy, empirical RAI therapy may be considered. However, the outcome data of TENIS syndrome without structural disease after empirical RAI therapy have not shown clear evidence of improvement in survival. We assessed the efficacy of such empirical RAI therapy in TENIS syndrome without structural disease and evaluated the progression-free survival (PFS). Methods A total of 80 papillary thyroid cancer (PTC) patients with TENIS syndrome without structural disease were included in this retrospective study. 52 patients were treated with empirical RAI therapy while another 28 patients were untreated. The progression-free survival (PFS) of both groups was defined as the main outcome. The secondary outcome was the comparison of serum Tg levels 12 months after being diagnosed as TENIS syndrome. Results The PFS of the empirical RAI therapy group was better than the untreated group (p < 0.001). Moreover, there was significant difference in Tg normalization between patients treated with empirical therapy and without treatment (p = 0.001). Empirical RAI therapy (p = 0.001) predicts better PFS. Male gender (p = 0.041) and empirical RAI therapy (p = 0.002) predict better remission in serum Tg level. Conclusion Patients with TENIS syndrome without structural disease can benefit from empirical RAI therapy in both PFS and Tg normalization..

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:37

Enthalten in:

Annals of nuclear medicine - 37(2022), 1 vom: 01. Nov., Seite 18-25

Sprache:

Englisch

Beteiligte Personen:

Yuan, Liyi [VerfasserIn]
Wang, Jing [VerfasserIn]
Pan, Liqin [VerfasserIn]
Feng, Huijuan [VerfasserIn]
Chen, Pan [VerfasserIn]
Luo, Jiaxin [VerfasserIn]
Xie, Jiahao [VerfasserIn]
Xiong, Xiaoli [VerfasserIn]
Wu, Juqing [VerfasserIn]
Ouyang, Wei [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

BKL:

44.64$jRadiologie

Themen:

Differentiated thyroid cancer
Empirical radioiodine therapy
TENIS syndrome
Thyroglobulin

Anmerkungen:

© The Author(s) under exclusive licence to The Japanese Society of Nuclear Medicine 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s12149-022-01799-5

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2133247815

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