An Update on the Misuse and Abuse Potential of Pharmacological Treatments for Central Disorders of Hypersomnolence
Purpose of Review All medications currently approved for the treatment of central disorders of hypersomnolence, with the exception of pitolisant, are scheduled substances. There is a perceived and real potential for misuse and abuse of traditional stimulants and sodium oxybate, with generally less concern for modafinil. Pitolisant and solriamfetol are newer approved agents with unique pharmacological profiles. In our paper, we aim to review the misuse and abuse potential of new and existing treatments for narcolepsy and idiopathic hypersomnia. Recent Findings Available preclinical, clinical, and post-marketing surveillance data on pitolisant, solriamfetol, and modafinil suggest that these agents have a very low potential for misuse and abuse. Agents that have high potential for misuse, specifically stimulants and sodium oxybate, most likely carry lower risks when used to treat narcolepsy or idiopathic hypersomnia compared to risks of misuse in the general population or among other neuropsychiatric conditions. Summary Approved therapies for central disorders of hypersomnolence carry low yet varying risks for misuse and abuse. Further studies in patients diagnosed with central disorders of hypersomnolence are required to comprehensively assess the misuse and abuse potential of these therapeutic agents..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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| Enthalten in: |
Current sleep medicine reports - 8(2022), 4 vom: 19. Sept., Seite 147-159 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ngo, Quang [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Abuse liability |
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| Anmerkungen: |
© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| doi: |
10.1007/s40675-022-00227-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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OLC2133155848 |
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| 245 | 1 | 0 | |a An Update on the Misuse and Abuse Potential of Pharmacological Treatments for Central Disorders of Hypersomnolence |
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| 520 | |a Purpose of Review All medications currently approved for the treatment of central disorders of hypersomnolence, with the exception of pitolisant, are scheduled substances. There is a perceived and real potential for misuse and abuse of traditional stimulants and sodium oxybate, with generally less concern for modafinil. Pitolisant and solriamfetol are newer approved agents with unique pharmacological profiles. In our paper, we aim to review the misuse and abuse potential of new and existing treatments for narcolepsy and idiopathic hypersomnia. Recent Findings Available preclinical, clinical, and post-marketing surveillance data on pitolisant, solriamfetol, and modafinil suggest that these agents have a very low potential for misuse and abuse. Agents that have high potential for misuse, specifically stimulants and sodium oxybate, most likely carry lower risks when used to treat narcolepsy or idiopathic hypersomnia compared to risks of misuse in the general population or among other neuropsychiatric conditions. Summary Approved therapies for central disorders of hypersomnolence carry low yet varying risks for misuse and abuse. Further studies in patients diagnosed with central disorders of hypersomnolence are required to comprehensively assess the misuse and abuse potential of these therapeutic agents. | ||
| 650 | 4 | |a Narcolepsy | |
| 650 | 4 | |a Idiopathic hypersomnia | |
| 650 | 4 | |a Excessive daytime sleepiness | |
| 650 | 4 | |a Substance abuse | |
| 650 | 4 | |a Abuse liability | |
| 650 | 4 | |a Addiction | |
| 700 | 1 | |a Plante, David T. |4 aut | |
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