Health-related quality of life in survivors of severe COVID-19 infection

Background Long-term effects of Coronavirus Disease 2019 (COVID-19) are increasingly recognized as having a significant impact on Health-Related Quality of Life (HRQoL). Understanding HRQoL status for each patient affected by long COVID-19 and its determinants may have a key role to prevent and treat this condition. Methods In this prospective observational study conducted in a large academic COVID-19 hospital in Rome, participants were contacted 2 years after hospital admission for severe COVID-19. To assess HRQoL, EQ-5D-5L and Visual analog scale (EQ VAS) standard questionnaires were administered by interview. Logistic regression model was used to the five health dimensions as dependent variables (0 = no problem, 1 = some/extreme problem). Key results In 137 enrolled patients, the mean pre-COVID and post-COVID EQ-5D-5L index and EQ-VAS score were 0.97 (SD 0.06), 0.79 (SD 0.26) and 72.38 (SD 15.18), respectively. After subdivision of the participants for clinical and social variables, the EQ-5D-5L index resulted significantly lower than in the pre-COVID-19 period. Female gender, unemployed status, and chronic comorbidities were the most common predictors for having any problems in each EQ-5D-5L domain, while also older age and higher Body Mass Index (BMI) showed to be related to a lower EQ-VAS score. Conclusion HRQoL showed to be still low in patients 2 years after acute severe COVID-19. Given the significant impact of SARS-CoV-2 on long-term chronic symptoms, predictors of poor outcomes must be considered during the acute phase of illness to plan a tailored follow-up path for each patient..

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:74

Enthalten in:

Pharmacological reports - 74(2022), 6 vom: 14. Nov., Seite 1286-1295

Sprache:

Englisch

Beteiligte Personen:

d’Ettorre, Gabriele [VerfasserIn]
Vassalini, Paolo [VerfasserIn]
Coppolelli, Vincenzo [VerfasserIn]
Gentilini Cacciola, Elio [VerfasserIn]
Sanitinelli, Letizia [VerfasserIn]
Maddaloni, Luca [VerfasserIn]
Fabris, Silvia [VerfasserIn]
Mastroianni, Claudio M. [VerfasserIn]
d’Ettorre, Gabriella [VerfasserIn]
Ceccarelli, Giancarlo [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

Themen:

COVID-19
HRQoL
Health-related quality of life
Post-COVID
Quality of life
SARS-CoV2

Anmerkungen:

© The Author(s) under exclusive licence to Maj Institute of Pharmacology Polish Academy of Sciences 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s43440-022-00433-5

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2133000550

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