Pharmaceutical Nanoarchitectonics: Molecular Pharmaceutics and Smart Delivery of β-Caryophyllene Constellated 5-FU Nanoinvasomes for Skin Cancer Therapy

Topical chemotherapeutics for skin cancer treatment display few pitfalls. Most of the antineoplastic drugs exhibit poor pharmacokinetics and low bioavailability. Hence, it is important to create a smart drug delivery system that can empower the transport properties of the drug along with an improved drug-skin partition coefficient. Invasomes are soft liposomal highly membrane fluidized vesicles. The ethanol and terpenes make invasomes as an excellent drug penetrant nanovehicle along with the shared benefits of liposomes. These nanovehicles with terpene-based natural penetration enhancers alter the order of stratum corneum cellular junctions and are emerging as promising drug transporters for enhanced skin delivery. A nucleobase analogous anticancer molecule 5-Fluorouracil (5-FU) acts as an antimetabolite inhibitor of DNA synthesis and retard the growth of carcinoma. The present investigation is intended to develop β-caryophyllene constellated nanoinvasomes of 5-fluorouracil (INV-FU). The INV-FU was analyzed by various characterization techniques, viz., PSA, zeta potential, TEM, SEM, DTA, and ATR-FTIR. The TEM and SEM images of the INV-FU nanoinvasomes showed uniform fluidized vesicles with smooth surface morphology and size ranging from 50 to 200 nm. The encapsulation efficiency of INV-FU was found to be 75.13% with a zeta potential value of − 23.6 mV. The ATR-FTIR spectrum of INV-FU confirmed the compatibility between 5-FU and lipid excipients. INV-FU shows a stereoselective molecular transport from the lipid matrix in a controlled fashion. In vitro anticancer assay against A-431 cell lines, antioxidant assay by DPPH inhibition and ex vivo skin deposition assay confirmed that INV-FU demonstrated higher efficacy as compared to the physical mixture of blank nanoformulation and pure drug 5-FU. The occlusivity test reveals sensible occlusive properties of INV-FU. These findings demonstrated the potential of INV-FU as a smart nanodermatic dosage form for skin cancer therapy. Graphical abstract.

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:12

Enthalten in:

BioNanoScience - 12(2022), 4 vom: 27. Sept., Seite 1329-1340

Sprache:

Englisch

Beteiligte Personen:

Bhardwaj, Prashant [VerfasserIn]
Dilbaghi, Neeraj [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

Themen:

β-Caryophyllene
5-Fluorouracil
Lipid carrier
Nanoarchitectonics
Skin cancer

Anmerkungen:

© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s12668-022-01036-3

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2132877599

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