Accrual of organ damage in Behçet’s syndrome: trajectory, associated factors, and impact on patients’ quality of life over a 2-year prospective follow-up study

Background This study aimed to investigate the trajectory of damage accrual, associated factors, and impact on health-related quality of life (HR-QoL) in a multicenter cohort of patients with Behçet’s syndrome (BS) over 2 years of follow-up. Methods Patients recruited in the BS Overall Damage Index (BODI) validation study were prospectively monitored for 2 years and assessed for damage accrual, defined as an increase ≥1 in the BODI score, and HR-QoL was evaluated by the SF-36 questionnaire. Logistic and multiple linear regression models were built to determine factors associated with damage accrual and impairment in the different SF-36 domains. Results During follow-up, 36 out of 189 (19.0%) patients had an increase ≥1 in the BODI score with a mean (SD) difference of 1.7 (0.8) (p <0.001). The incidence rate of damage accrual was stable over time, regardless of the disease duration. Out of 61 new BODI items, 25 (41.0%) were considered related to glucocorticoid (GC) use. In multivariate analysis, duration of GC therapy (OR per 1-year 1.15, 95% CI 1.07–1.23; p <0.001) and occurrence of ≥1 disease relapse (OR 3.15, 95% CI 1.09–9.12; p 0.038) were identified as predictors of damage accrual, whereas the use of immunosuppressants showed a protective effect (OR 0.20, 95% CI 0.08–0.54, p<0.001). Damage accrual was independently associated with the impairment of different physical domains and, to a greater extent, in emotional domains of the SF-36 questionnaire. Female sex, higher disease activity, and fibromyalgia were also significantly associated with impairment in HR-QoL. Conclusion In BS, organ damage accrues over time, also in long-standing disease, resulting in an impairment of the perceived physical and mental health. Adequate immunosuppressive treatment, preventing disease flares and minimizing exposure to GCs have a crucial role in lowering the risk of damage accrual..

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:24
Enthalten in:	Arthritis Research & Therapy - 24(2022), 1 vom: 17. Nov.

Sprache:	Englisch

Beteiligte Personen:

Floris, Alberto [VerfasserIn] Piga, Matteo [VerfasserIn] Laconi, Riccardo [VerfasserIn] Espinosa, Gerard [VerfasserIn] Lopalco, Giuseppe [VerfasserIn] Serpa Pinto, Luisa [VerfasserIn] Kougkas, Nikolaos [VerfasserIn] Sota, Jurgen [VerfasserIn] Lo Monaco, Andrea [VerfasserIn] Govoni, Marcello [VerfasserIn] Cantarini, Luca [VerfasserIn] Bertsias, George [VerfasserIn] Correia, João [VerfasserIn] Iannone, Florenzo [VerfasserIn] Cervera, Ricard [VerfasserIn] Vasconcelos, Carlos [VerfasserIn] Mathieu, Alessandro [VerfasserIn] Cauli, Alberto [VerfasserIn]

Links:	Volltext [kostenfrei]

Anmerkungen:	© The Author(s) 2022

doi:	10.1186/s13075-022-02947-y

funding:
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PPN (Katalog-ID):	OLC2132776032