COVID-19 vaccination, implications for PET/CT image interpretation and future perspectives

Introduction The present paper aims to systematically review the literature on COVID-19 vaccine-related findings in patients undergoing PET/CT. Methods The search algorithms included the following combination of terms: “PET” OR “positron emission tomography” AND “COVID”; “PET” OR “positron emission tomography” AND “COVID” AND “vaccination”; “PET” OR “positron emission tomography” AND “COVID”, AND “autoimmune”. Results We selected 17 articles which were assessed for quality and included in the systematic analysis. The most frequent vaccine-related signs on PET/CT were the deltoid [18F]FDG uptake and axillary hypermetabolic lymph nodes, which were described in 8–71% and 7–90% of the patients, respectively. Similarly, frequency of these findings using other tracers than [18F]FDG was greatly variable. This large variability was related to the variability in time elapsed between vaccination and PET/CT, and the criteria used to define positivity. In addition, vaccine-related findings were detected more frequently in young and immunocompetent patients than in elderly and immunocompromised ones. Discussion Therefore, awareness on vaccination status (timing, patient characteristics, and concurrent therapies) and knowledge on patterns of radiopharmaceutical uptake are necessary to properly interpret PET/CT findings..

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:10

Enthalten in:

Clinical and translational imaging - 10(2022), 6 vom: 16. Aug., Seite 631-642

Sprache:

Englisch

Beteiligte Personen:

Kirienko, Margarita [VerfasserIn]
Biroli, Matteo [VerfasserIn]
Pini, Cristiano [VerfasserIn]
Gelardi, Fabrizia [VerfasserIn]
Sollini, Martina [VerfasserIn]
Chiti, Arturo [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

Themen:

COVID-19
Infection
Inflammation
PET/CT
SARS-CoV-2
Vaccination

Anmerkungen:

© The Author(s), under exclusive licence to Italian Association of Nuclear Medicine and Molecular Imaging 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s40336-022-00521-9

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC213271729X

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