Sociodemographic factors associated with Wilms tumor treatment and survival: a population-based study

Introduction Though Wilms tumor (WT) is one of the most common malignancies in children, there is a paucity of epidemiologic studies exploring sociodemographic disparities in treatment and survival. Here, we leveraged a national cancer registry to examine sociodemographic factors associated with receipt of adjuvant therapy, either chemotherapy or radiation, as well as overall survival among pediatric patients with WT. Materials and methods Within the Surveillance Epidemiology and End Results database (2000–2016), we identified 2043 patients (≤ 20 years of age) with unilateral WT. Multivariable logistic regression and Cox proportional hazard models were constructed to examine the association of sociodemographic factors with, respectively, adjuvant chemotherapy/radiotherapy and overall survival (OS). Results Patients in the lowest SES quintile (OR 0.56, 95% CI 0.33–0.93, p = 0.03) were less likely to receive chemotherapy as compared to those in the highest SES quintile, though this association did not persist in sensitivity analyses including only patients at least 2 years of age and patients with regional/distant disease. In addition, female patients were more likely to receive chemotherapy (OR 1.46, 95% CI 1.08–1.97, p = 0.02) than male patients. Age, race, year of diagnosis, insurance status, and tumor laterality were not associated with receipt of chemotherapy. No sociodemographic variables were associated with receipt of radiotherapy. Lastly, as compared to Non-Hispanic-White patients, Hispanic patients had worse OS (HR 1.59, 95% CI 1.08–2.35, p = 0.02); no other sociodemographic variables were associated with OS. Conclusions This study suggests multilevel sociodemographic disparities involving ethnicity and SES in WT treatment and survival..

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:54

Enthalten in:

International urology and nephrology - 54(2022), 12 vom: 07. Sept., Seite 3055-3062

Sprache:

Englisch

Beteiligte Personen:

Bhambhvani, Hriday P. [VerfasserIn]
Peterson, Dylan J. [VerfasserIn]
Sheth, Kunj R. [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

BKL:

44.88$jUrologie$jNephrologie

Themen:

Children
Kidney
Nephroblastoma
Oncology
Renal

Anmerkungen:

© The Author(s), under exclusive licence to Springer Nature B.V. 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s11255-022-03343-w

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2132508607

Zugang & Verfügbarkeit




Zugehörige Publikationen/Bände

    Haven't found what you're looking for?