Details der Publikation - The role of MBL, PCT, CRP, neutrophil–lymphocyte ratio, and platelet lymphocyte ratio in differentiating infections from flares in lupus

The role of MBL, PCT, CRP, neutrophil–lymphocyte ratio, and platelet lymphocyte ratio in differentiating infections from flares in lupus

Background The distinction between infection and flare in systemic lupus erythematosus (SLE) has always been a dilemma for clinicians as the clinical and biochemical profiles overlap. The present study evaluated affordable biomarkers to distinguish infection from flare in an SLE cohort in a tertiary care center in eastern India. Methods One hundred and fifty-two SLE patients were clinically evaluated and enrolled in the present study. Hematological, immunological, and biochemical profiles and various biomarkers such as C reactive protein (CRP), procalcitonin (PCT), and Mannose-binding lectin (MBL) were quantified. Results One hundred and fifty-two patients (152) were enrolled in the present study and all had SLEDAI scores of more than 4. From which 70 had infection, and the common infections were urinary tract infection (34.28%) followed by pneumonia (27.14%). Neutrophil–lymphocyte ratio (NLR) and C-reactive protein (CRP) were significantly elevated in SLE with infections (NLR: 5.84 ± 2.47; CRP: 30.56 ± 41.63) than those with flare (NLR: 3.87 ± 2.62; CRP: 8.73 ± 9.53). The receiver operating characteristic curve (ROC) analysis revealed CRP, PLR, and NLR as important markers for predicting infections (CRP: AUC = 0.682, p = 0.0001; PLR: AUC = 0.668, p = 0.0008; NLR: AUC = 0.742, p < 0.0001). The MBL and PCT levels were comparable among SLE flare and those with infections. Conclusions NLR and CRP levels are affordable biomarkers to distinguish infections from flares in SLE. MBL and PCT could not differentiate flare from an infection.Key Points• Biomarkers for the differentiation of infection and flare in SLE are limited.• NLR, PLR, and CRP are promising biomarkers to enable differentiation.• PCT and MBL are not ideal biomarkers to differentiate infection from flare..

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:41
Enthalten in:	Clinical rheumatology - 41(2022), 11 vom: 14. Juli, Seite 3337-3344

Sprache:	Englisch

Beteiligte Personen:	Musunuri, Balaji [VerfasserIn] Tripathy, Rina [VerfasserIn] Padhi, Sunali [VerfasserIn] Panda, Aditya K. [VerfasserIn] Das, Bidyut K. [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.00$jMedizin: Allgemeines 44.83$jRheumatologie$jOrthopädie
Themen:	Biomarkers C reactive protein Flare Infection Mannose-binding lectin Neutrophil–lymphocyte ratio PCT Systemic lupus erythematosus

Anmerkungen:	© The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR) 2022

doi:	10.1007/s10067-022-06285-x

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2132378118

Internformat


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245	1	0	\|a The role of MBL, PCT, CRP, neutrophil–lymphocyte ratio, and platelet lymphocyte ratio in differentiating infections from flares in lupus
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520			\|a Background The distinction between infection and flare in systemic lupus erythematosus (SLE) has always been a dilemma for clinicians as the clinical and biochemical profiles overlap. The present study evaluated affordable biomarkers to distinguish infection from flare in an SLE cohort in a tertiary care center in eastern India. Methods One hundred and fifty-two SLE patients were clinically evaluated and enrolled in the present study. Hematological, immunological, and biochemical profiles and various biomarkers such as C reactive protein (CRP), procalcitonin (PCT), and Mannose-binding lectin (MBL) were quantified. Results One hundred and fifty-two patients (152) were enrolled in the present study and all had SLEDAI scores of more than 4. From which 70 had infection, and the common infections were urinary tract infection (34.28%) followed by pneumonia (27.14%). Neutrophil–lymphocyte ratio (NLR) and C-reactive protein (CRP) were significantly elevated in SLE with infections (NLR: 5.84 ± 2.47; CRP: 30.56 ± 41.63) than those with flare (NLR: 3.87 ± 2.62; CRP: 8.73 ± 9.53). The receiver operating characteristic curve (ROC) analysis revealed CRP, PLR, and NLR as important markers for predicting infections (CRP: AUC = 0.682, p = 0.0001; PLR: AUC = 0.668, p = 0.0008; NLR: AUC = 0.742, p < 0.0001). The MBL and PCT levels were comparable among SLE flare and those with infections. Conclusions NLR and CRP levels are affordable biomarkers to distinguish infections from flares in SLE. MBL and PCT could not differentiate flare from an infection.Key Points• Biomarkers for the differentiation of infection and flare in SLE are limited.• NLR, PLR, and CRP are promising biomarkers to enable differentiation.• PCT and MBL are not ideal biomarkers to differentiate infection from flare.
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The role of MBL, PCT, CRP, neutrophil–lymphocyte ratio, and platelet lymphocyte ratio in differentiating infections from flares in lupus

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