Endogenous Adenosine 5′-Monophosphate, But Not Acetylcholine or Histamine, is Associated with Asthma Control, Quality of Life, and Exacerbations

Objective Endogenous adenosine 5′-monophosphate (AMP), acetylcholine (ACh), and histamine (HA) are known to be important in bronchial contraction, but their clinical relevance to asthma is poorly understood. We aimed to quantify endogenous AMP, ACh, and HA in induced sputum samples and explore their relationships with asthma control and exacerbations. Methods 20 healthy subjects and 112 asthmatics underwent clinical assessment, sputum induction, and blood sampling. The level of asthma control was determined by the asthma control test (ACT) questionnaire. Asthma exacerbation was evaluated according to the criteria of the American Thoracic Society/European Respiratory Society. Levels of AMP, ACh, and HA in sputum were measured by liquid chromatography coupled to tandem mass spectrometry. IL-β, IL-4, IL-5, IL-6, IL-8, IL-13, IL-17A, TNF-α, IFN-γ, and macrophage-derived chemokine (MDC) were also measured. Results Compared to healthy controls, asthmatics had higher levels of HA, lower levels of ACh, and similar levels of AMP in induced sputum samples. Compared to controlled asthma (n = 54), uncontrolled asthma (n = 58) showed higher AMP levels (P = 0.002), but similar HA and ACh levels. AMP was negatively correlated with ACT scores (r = − 0.348) and asthma quality of life questionnaire scores (r = − 0.188) and positively correlated with blood monocytes percentage (r = 0.195), sputum MDC (r = 0.214), and IL-6 levels (r = 0.196). Furthermore, AMP was associated with an increased risk of exacerbations in the preceding year. Conclusion Endogenous AMP, but not ACh or HA, was associated with asthma control, quality of life, and exacerbations in the previous year, which indicates that AMP could be a clinically useful biomarker of asthma..

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:200

Enthalten in:

Lung - 200(2022), 5 vom: 26. Sept., Seite 579-589

Sprache:

Englisch

Beteiligte Personen:

Fang, Xue Mei [VerfasserIn]
Liu, Ying [VerfasserIn]
Wang, Ji [VerfasserIn]
Zhang, Xin [VerfasserIn]
Wang, Lei [VerfasserIn]
Zhang, Li [VerfasserIn]
Zhang, Hong Ping [VerfasserIn]
Liu, Lei [VerfasserIn]
Huang, Dan [VerfasserIn]
Liu, Dan [VerfasserIn]
Deng, Ke [VerfasserIn]
Luo, Feng Ming [VerfasserIn]
Wan, Hua Jing [VerfasserIn]
Li, Wei Min [VerfasserIn]
Wang, Gang [VerfasserIn]
Oliver, Brian G. [VerfasserIn]

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Volltext [lizenzpflichtig]

BKL:

44.84$jPulmologie

Themen:

Acetylcholine
Adenosine 5′-monophosphate
Asthma control
Asthma exacerbation
Histamine

Anmerkungen:

© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s00408-022-00570-x

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC213224796X

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