Details der Publikation - Secondary respiratory early and late infections in mechanically ventilated patients with COVID-19

Secondary respiratory early and late infections in mechanically ventilated patients with COVID-19

Background Patients with COVID-19 receiving mechanical ventilation may become aggravated with a secondary respiratory infection. The aim of this study was to describe secondary respiratory infections, their predictive factors, and outcomes in patients with COVID-19 requiring mechanical ventilation. Methods A cohort study was carried out in a single tertiary hospital in Santiago, Chile, from 1st June to 31st July 2020. All patients with COVID-19 admitted to the intensive care unit that required mechanical ventilation were included. Results A total of 175 patients were enrolled, of which 71 (40.6%) developed at least one secondary respiratory infection during follow-up. Early and late secondary infections were diagnosed in 1.7% and 31.4% respectively. Within late secondary infections, 88% were bacterial, 10% were fungal, and 2% were of viral origin. One-third of isolated bacteria were multidrug-resistant. Bivariate analysis showed that the history of corticosteroids used before admission and the use of dexamethasone during hospitalization were associated with a higher risk of secondary infections (p = 0.041 and p = 0.019 respectively). Multivariate analysis showed that for each additional day of mechanical ventilation, the risk of secondary infection increases 1.1 times (adOR = 1.07; 95% CI 1.02–1.13, p = 0.008) Conclusions Patients with COVID-19 admitted to the intensive care unit and requiring mechanical ventilation had a high rate of secondary infections during their hospital stay. The number of days on MV was a risk factor for acquiring secondary respiratory infections..

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:22
Enthalten in:	BMC infectious diseases - 22(2022), 1 vom: 29. Sept.

Sprache:	Englisch

Beteiligte Personen:	Ceballos, María Elena [VerfasserIn] Nuñez, Carolina [VerfasserIn] Uribe, Javier [VerfasserIn] Vera, María Magdalena [VerfasserIn] Castro, Ricardo [VerfasserIn] García, Patricia [VerfasserIn] Arriata, Gabriel [VerfasserIn] Gándara, Vicente [VerfasserIn] Vargas, Camila [VerfasserIn] Dominguez, Angélica [VerfasserIn] Cerón, Inés [VerfasserIn] Born, Pablo [VerfasserIn] Espíndola, Eduardo [VerfasserIn]

Links:	Volltext [kostenfrei]

Themen:	COVID-19 Coinfections ICU Mechanical ventilation SARS-CoV-2 Secondary infections

Anmerkungen:	© The Author(s) 2022

doi:	10.1186/s12879-022-07743-2

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2132224331

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520			\|a Background Patients with COVID-19 receiving mechanical ventilation may become aggravated with a secondary respiratory infection. The aim of this study was to describe secondary respiratory infections, their predictive factors, and outcomes in patients with COVID-19 requiring mechanical ventilation. Methods A cohort study was carried out in a single tertiary hospital in Santiago, Chile, from 1st June to 31st July 2020. All patients with COVID-19 admitted to the intensive care unit that required mechanical ventilation were included. Results A total of 175 patients were enrolled, of which 71 (40.6%) developed at least one secondary respiratory infection during follow-up. Early and late secondary infections were diagnosed in 1.7% and 31.4% respectively. Within late secondary infections, 88% were bacterial, 10% were fungal, and 2% were of viral origin. One-third of isolated bacteria were multidrug-resistant. Bivariate analysis showed that the history of corticosteroids used before admission and the use of dexamethasone during hospitalization were associated with a higher risk of secondary infections (p = 0.041 and p = 0.019 respectively). Multivariate analysis showed that for each additional day of mechanical ventilation, the risk of secondary infection increases 1.1 times (adOR = 1.07; 95% CI 1.02–1.13, p = 0.008) Conclusions Patients with COVID-19 admitted to the intensive care unit and requiring mechanical ventilation had a high rate of secondary infections during their hospital stay. The number of days on MV was a risk factor for acquiring secondary respiratory infections.
650		4	\|a Coinfections
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Secondary respiratory early and late infections in mechanically ventilated patients with COVID-19

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