Survival times of patients with glioblastoma in low- and middle-income countries: a systematic review and meta-analysis

Abstract Little is known about the survivorship of glioblastoma (GBM) patients in low- and middle-income countries (LMICs). We hypothesize that this would be lower than published figures for high-income countries due to cancer health disparities. We performed a systematic review and meta-analysis to estimate the median overall survival (OS) of GBM in LMICs and determine factors affecting OS. A systematic review of 12 electronic databases was conducted according to PRISMA guidelines to identify studies of newly diagnosed adult GBM patients done in countries classified as LMIC by the World Bank (WB) from inception to December 2020. Random effects meta-analysis of collected median overall survival data was done. Subgroup analysis and meta-regression were done to determine if WB income classification (WBIC), start year of recruitment (pre- or post-popularization of the standard Stupp protocol), and treatment modality affected OS. The 24 articles (n = 2,552) that met the inclusion criteria were from 8 low-middle income and upper-middle income countries, with 0 articles from low-income countries. Random effects analysis of 24 studies showed a pooled median OS of 14.17 months (95% CI 12.90–15.43, I2 = 79). Subgroup analysis showed a significant difference (p < 0.05) in the pooled median OS of studies predating Stupp protocol (12.54 mo, 95% CI 11.13–13.96, I2 = 80%; n = 1027) and studies postdating Stupp protocol (15.64 mo, 95% CI 13.58–17.69, I2 = 77; n = 1412). Subgroup analysis of WBIC and treatment modalities did not show significant differences. Published data on the survivorship of GBM patients in LMICs is sparse, highlighting the need for good quality pragmatic studies from LMICs. The limited evidence suggests improving survivorship after introduction of the Stupp protocol..

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:45

Enthalten in:

Neurosurgical review - 45(2022), 5 vom: 31. Aug., Seite 3393-3403

Sprache:

Englisch

Beteiligte Personen:

Dy, Louie F. [VerfasserIn]
Ong, Erika P. [VerfasserIn]
Espiritu, Adrian I. [VerfasserIn]
Spears, Julian [VerfasserIn]
Omar, Abdelsimar T. [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

BKL:

44.65$jChirurgie

44.90$jNeurologie

Themen:

Glioblastoma multiforme
Global neuro-oncology
Low-middle-income countries (LMIC)
Meta-analysis
Survival times
Systematic review

Anmerkungen:

© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s10143-022-01844-x

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2132108730

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