Metabolomics for exposure assessment and toxicity effects of occupational pollutants: current status and future perspectives

Introduction Work-related exposures to harmful agents or factors are associated with an increase in incidence of occupational diseases. These exposures often represent a complex mixture of different stressors, challenging the ability to delineate the mechanisms and risk factors underlying exposure-disease relationships. The use of omics measurement approaches that enable characterization of biological marker patterns provide internal indicators of molecular alterations, which could be used to identify bioeffects following exposure to a toxicant. Metabolomics is the comprehensive analysis of small molecule present in biological samples, and allows identification of potential modes of action and altered pathways by systematic measurement of metabolites. Objectives The aim of this study is to review the application of metabolomics studies for use in occupational health, with a focus on applying metabolomics for exposure monitoring and its relationship to occupational diseases. Methods PubMed, Web of Science, Embase and Scopus electronic databases were systematically searched for relevant studies published up to 2021. Results Most of reviewed studies included worker populations exposed to heavy metals such as As, Cd, Pb, Cr, Ni, Mn and organic compounds such as tetrachlorodibenzo-p-dioxin, trichloroethylene, polyfluoroalkyl, acrylamide, polyvinyl chloride. Occupational exposures were associated with changes in metabolites and pathways, and provided novel insight into the relationship between exposure and disease outcomes. The reviewed studies demonstrate that metabolomics provides a powerful ability to identify metabolic phenotypes and bioeffect of occupational exposures. Conclusion Continued application to worker populations has the potential to enable characterization of thousands of chemical signals in biological samples, which could lead to discovery of new biomarkers of exposure for chemicals, identify possible toxicological mechanisms, and improved understanding of biological effects increasing disease risk associated with occupational exposure..

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:18

Enthalten in:

Metabolomics - 18(2022), 9 vom: 09. Sept.

Sprache:

Englisch

Beteiligte Personen:

Dehghani, Fatemeh [VerfasserIn]
Yousefinejad, Saeed [VerfasserIn]
Walker, Douglas I. [VerfasserIn]
Omidi, Fariborz [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

BKL:

42.15$jZellbiologie

Themen:

Biomarkers
Exposome
Exposure assessment
Metabolomics
Occupational health
Toxicology

Anmerkungen:

© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s11306-022-01930-7

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2131963386

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