Amyloidosis and COVID-19: experience from an amyloid program in Canada

Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV2) and associated COVID-19 infection continue to impact patients globally. Patients with underlying health conditions are at heightened risk of adverse outcomes from COVID-19; however, research involving patients with rare health conditions remains scarce. The amyloidoses are a rare grouping of protein deposition diseases. Light-chain and transthyretin amyloidosis are the most common disease forms, often present with systemic involvement of vital organs including the heart, nerves, kidneys, and GI tracts of affected individuals. The Amyloidosis Program of Calgary examined 152 ATTR patients and 103 AL patients analyzing rates of vaccination, COVID-19 testing, infection outcomes, influence referrals, and excess deaths. Results showed 15 total PCR-confirmed COVID-19 infections in the tested population of amyloid patients, with a higher frequency of infections among patient with AL compared to the ATTR cohort (26.2% vs 5.1%). Four patients (26.6%) required hospital admission for COVID-19 infection, 2 ATTR, and 2 AL patients. Of the confirmed cases, 1 (0.07%) unvaccinated ATTR patient died of a COVID-19 infection. An excess of deaths was found in both the ATTR and AL cohorts when comparing pre-pandemic years 2018 and 2019 to the pandemic years of 2020 and 2021. The finding suggests that amyloidosis patients are likely at a high risk for severe COVID-19 infection and mortality, especially those of advanced age, those on an active treatment with chemotherapy, and those with concomitant B-cell or plasma cell disorder. The impact of virtual healthcare visits and pandemic measures on the excess of deaths observed requires further research..

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:101

Enthalten in:

Annals of hematology - 101(2022), 10 vom: 26. Aug., Seite 2307-2315

Sprache:

Englisch

Beteiligte Personen:

Lewis, Ellen [VerfasserIn]
Fine, Nowell [VerfasserIn]
Miller, Robert J. H. [VerfasserIn]
Hahn, Christopher [VerfasserIn]
Chhibber, Sameer [VerfasserIn]
Mahe, Etienne [VerfasserIn]
Tay, Jason [VerfasserIn]
Duggan, Peter [VerfasserIn]
McCulloch, Sylvia [VerfasserIn]
Bahlis, Nizar [VerfasserIn]
Neri, Paola [VerfasserIn]
Jimenez-Zepeda, Victor H. [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

Themen:

Amyloid
COVID-19
Light-chain amyloidosis
SARS CoV2
Transthyretin amyloidosis

RVK:

RVK Klassifikation

Anmerkungen:

© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s00277-022-04964-y

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2131953267

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