Details der Publikation - Predictive factors of glomerular filtration rate loss associated with living kidney donation: a single-center retrospective study

Predictive factors of glomerular filtration rate loss associated with living kidney donation: a single-center retrospective study

Purpose Living kidney donors (LKD) partially compensate the initial loss of glomerular filtration rate (GFR), a phenomenon known as renal functional reserve (RFR). RFR is reduced in the elderly, a population with increased prevalence of chronic kidney disease. We hypothesized that the selected, healthy population of LKD, would specifically inform about the physiological determinants of the RFR and studied it using measured GFR (mGFR). Methods We retrospectively analyzed pre-donation and post-donation mGFR in 76 LKD from Tenon Hospital (Paris, France) between 2002 and 2018. In addition to GFR measurements, we collected pre-donation morphologic parameters, demographic data, and kidney volumes. Results Mean pre-donation mGFR was 90.11 ± 12.64 mL/min/1.73 $ m^{2} $ and decreased to 61.26 ± 9.57 mL/min/1.73 $ m^{2} $ 1 year after donation. Pre-donation mGFR correlated with age (p = 0.0003), total kidney volume (p = 0.0004) and pre-donation serum creatinine (p = 0.0453). Pre-donation mGFR strongly predicted 1-year post-donation mGFR. Mean RFR (increase in GFR of the remnant kidney between pre-donation and post-donation) was 36.67 ± 16.67% 1 year after donation. In the multivariate linear model, RFR was negatively correlated to total kidney volume (p = 0.02) but not with age or pre-donation serum creatinine. Conclusions We found that pre-donation mGFR decreases with age and identified low total kidney volume as a predictor of RFR in healthy individuals. This suggests an adaptative and reversible decrease in kidney function rather than age-related damage. Older subjects may have reduced metabolic requirements with subsequent reduction in glomerular filtration and kidney volume and preserved RFR. Therefore, low GFR in older subjects should not preclude kidney donation..

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:40
Enthalten in:	World journal of urology - 40(2022), 9 vom: 20. Mai, Seite 2161-2168

Sprache:	Englisch

Beteiligte Personen:	Orieux, Arthur [VerfasserIn] Bouchet, Antonin [VerfasserIn] Doreille, Alice [VerfasserIn] Paslaru, Liliana [VerfasserIn] Livrozet, Marine [VerfasserIn] Haymann, Jean-Philippe [VerfasserIn] Ouali, Nacera [VerfasserIn] Mesnard, Laurent [VerfasserIn] Letavernier, Emmanuel [VerfasserIn] Galichon, Pierre [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	GFR decrease risk stratification Glomerular hyperfiltration Kidney transplantation Living kidney donation Renal functional reserve

RVK:	RVK Klassifikation ELIB24

Anmerkungen:	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022

doi:	10.1007/s00345-022-04019-x

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC213186342X

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520			\|a Purpose Living kidney donors (LKD) partially compensate the initial loss of glomerular filtration rate (GFR), a phenomenon known as renal functional reserve (RFR). RFR is reduced in the elderly, a population with increased prevalence of chronic kidney disease. We hypothesized that the selected, healthy population of LKD, would specifically inform about the physiological determinants of the RFR and studied it using measured GFR (mGFR). Methods We retrospectively analyzed pre-donation and post-donation mGFR in 76 LKD from Tenon Hospital (Paris, France) between 2002 and 2018. In addition to GFR measurements, we collected pre-donation morphologic parameters, demographic data, and kidney volumes. Results Mean pre-donation mGFR was 90.11 ± 12.64 mL/min/1.73 $ m^{2} $ and decreased to 61.26 ± 9.57 mL/min/1.73 $ m^{2} $ 1 year after donation. Pre-donation mGFR correlated with age (p = 0.0003), total kidney volume (p = 0.0004) and pre-donation serum creatinine (p = 0.0453). Pre-donation mGFR strongly predicted 1-year post-donation mGFR. Mean RFR (increase in GFR of the remnant kidney between pre-donation and post-donation) was 36.67 ± 16.67% 1 year after donation. In the multivariate linear model, RFR was negatively correlated to total kidney volume (p = 0.02) but not with age or pre-donation serum creatinine. Conclusions We found that pre-donation mGFR decreases with age and identified low total kidney volume as a predictor of RFR in healthy individuals. This suggests an adaptative and reversible decrease in kidney function rather than age-related damage. Older subjects may have reduced metabolic requirements with subsequent reduction in glomerular filtration and kidney volume and preserved RFR. Therefore, low GFR in older subjects should not preclude kidney donation.
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Predictive factors of glomerular filtration rate loss associated with living kidney donation: a single-center retrospective study

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