Major depressive disorder and attenuated negative symptoms in a child and adolescent sample with psychosis risk syndrome: the CAPRIS study

Abstract Some 70–80% of subjects with psychotic risk syndrome (PRS) have lifetime comorbidity, with depressive disorders being the most common. A high proportion of patients with PRS present nonspecific symptoms which can be confounding factors for diagnosis. Depressive and negative symptoms may be difficult to distinguish and it is important to differentiate them. The aim of this study is to assess the presence of depressive disorder in a child and adolescent sample of PRS and to examine the presence of negative symptoms and detect possible confounding characteristics between them and depressive symptoms. This is a naturalistic multi-site study with subjects who met PRS criteria. A sample of 89 PRS adolescent patients was included. Major depressive disorder (MDD) is the most prevalent comorbid disorder (34.83%). The sample was divided into patients who met criteria for MDD (PRS-MDD, n = 31) and those who did not have this disorder (PRS-ND, n = 44). We obtained significant differences in the attenuated negative symptoms (ANS) between PRS-MDD and PRS-ND (68.18 vs. 90.32%, respectively, p = 0.021). Subjects with MDD presented a higher score in ANS and Hamilton Depression Rating Scale (HDRS). Moreover, we obtained a correlation between negative symptomatology and HDRS score with a higher score on HDRS in subjects with higher negative symptom scores (r = 0.533, p < 0.001). More research is needed to fine tune differentiation between depressive and negative symptoms and learn more about the possible impact of MDD on PRS children and adolescents..

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:31

Enthalten in:

European child & adolescent psychiatry - 31(2021), 9 vom: 24. Apr., Seite 1431-1440

Sprache:

Englisch

Beteiligte Personen:

Rodríguez-Pascual, Marta [VerfasserIn]
Álvarez-Subiela, Xavier [VerfasserIn]
Tor, Jordina [VerfasserIn]
Pardo, Marta [VerfasserIn]
de la Serna, Elena [VerfasserIn]
Sugranyes, Gisela [VerfasserIn]
Puig, Olga [VerfasserIn]
Baeza, Inmaculada [VerfasserIn]
Dolz, Montserrat [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

BKL:

77.00$jPsychologie: Allgemeines

44.91$jPsychiatrie$jPsychopathologie

44.67$jKinderheilkunde

Themen:

Attenuated negative symptoms
Child and adolescent
Depressive disorder
Psychosis
Psychosis risk syndrome

RVK:

RVK Klassifikation

Anmerkungen:

© Springer-Verlag GmbH Germany, part of Springer Nature 2021

doi:

10.1007/s00787-021-01793-8

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2131795572

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