Details der Publikation - Effect of maternal vitamin D status on risk of adverse birth outcomes: a systematic review and dose–response meta-analysis of observational studies

Effect of maternal vitamin D status on risk of adverse birth outcomes: a systematic review and dose–response meta-analysis of observational studies

Purpose Accumulating evidence suggests that vitamin D deficiency increases the risk of adverse perinatal outcomes. However, the dose–response relationship between maternal vitamin D status and adverse birth outcomes remains unclear. Focusing on prospective observational studies, we aimed to explore the dose–response relationship of vitamin D status with the risk of low birth weight (LBW), macrosomia (MA), preterm birth (PTB), small for gestational age (SGA), and intrauterine growth restriction (IUGR). Methods Databases including PubMed, Embase, Scopus, and Web of Science were used up to 19 January 2021 to search for observational studies that fulfilled criteria as follows: cohort studies, case–cohort studies, or nested case–control studies. Random-effects models were used to pool relative risks (RRs) and 95% confidence intervals (CIs) in the observational studies. Results A total of 72 publications were included in this systematic review and 71 in the meta-analysis. Maternal 25-hydroxyvitamin D (25(OH)D) concentrations were inversely associated with the risk of LBW (RR: 0.65; 95% CI 0.48–0.86), PTB (RR: 0.67; 95% CI 0.57–0.79), and SGA (RR: 0.61; 95% CI 0.49–0.76) in the highest versus lowest meta-analysis, but not associated with MA and IUGR. Linear dose–response analysis showed that each 25 nmol/L increase in 25(OH)D was associated with a 6% and 10% reduction in the risk of PTB (RR: 0.94; 95% CI 0.90–0.98) and SGA (RR: 0.90; 95% CI 0.84–0.97), respectively. Conclusion Our study suggests that a sufficient vitamin D status during pregnancy is protective against the risk of LBW, PTB, and SGA..

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:61
Enthalten in:	European journal of nutrition - 61(2022), 6 vom: 22. März, Seite 2881-2907

Sprache:	Englisch

Beteiligte Personen:	Zhao, Rui [VerfasserIn] Zhou, Leilei [VerfasserIn] Wang, Shanshan [VerfasserIn] Yin, Heng [VerfasserIn] Yang, Xuefeng [VerfasserIn] Hao, Liping [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.21$jErnährung$XMedizin
Themen:	Birth outcomes Meta-analysis Pregnancy Prospective study Vitamin D

RVK:	RVK Klassifikation ELIB10 ELIB09 ELIB24

Anmerkungen:	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022

doi:	10.1007/s00394-022-02866-3

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2131621450

Internformat


LEADER	01000naa a22002652 4500
001	OLC2131621450
003	DE-627
005	20230506052428.0
007	cr uuu---uuuuu
008	230506s2022 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.1007/s00394-022-02866-3 \|2 doi
035			\|a (DE-627)OLC2131621450
035			\|a (DE-He213)s00394-022-02866-3-e
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
082	0	4	\|a 610 \|q VZ
082	0	4	\|a 630 \|a 640 \|a 610 \|q VZ
084			\|a ELIB10 \|q VZ \|2 rvk
084			\|a ELIB09 \|q VZ \|2 rvk
084			\|a ELIB24 \|q VZ \|2 rvk
084			\|a 44.21$jErnährung$XMedizin \|2 bkl
100	1		\|a Zhao, Rui \|e verfasserin \|4 aut
245	1	0	\|a Effect of maternal vitamin D status on risk of adverse birth outcomes: a systematic review and dose–response meta-analysis of observational studies
264		1	\|c 2022
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
500			\|a © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022
520			\|a Purpose Accumulating evidence suggests that vitamin D deficiency increases the risk of adverse perinatal outcomes. However, the dose–response relationship between maternal vitamin D status and adverse birth outcomes remains unclear. Focusing on prospective observational studies, we aimed to explore the dose–response relationship of vitamin D status with the risk of low birth weight (LBW), macrosomia (MA), preterm birth (PTB), small for gestational age (SGA), and intrauterine growth restriction (IUGR). Methods Databases including PubMed, Embase, Scopus, and Web of Science were used up to 19 January 2021 to search for observational studies that fulfilled criteria as follows: cohort studies, case–cohort studies, or nested case–control studies. Random-effects models were used to pool relative risks (RRs) and 95% confidence intervals (CIs) in the observational studies. Results A total of 72 publications were included in this systematic review and 71 in the meta-analysis. Maternal 25-hydroxyvitamin D (25(OH)D) concentrations were inversely associated with the risk of LBW (RR: 0.65; 95% CI 0.48–0.86), PTB (RR: 0.67; 95% CI 0.57–0.79), and SGA (RR: 0.61; 95% CI 0.49–0.76) in the highest versus lowest meta-analysis, but not associated with MA and IUGR. Linear dose–response analysis showed that each 25 nmol/L increase in 25(OH)D was associated with a 6% and 10% reduction in the risk of PTB (RR: 0.94; 95% CI 0.90–0.98) and SGA (RR: 0.90; 95% CI 0.84–0.97), respectively. Conclusion Our study suggests that a sufficient vitamin D status during pregnancy is protective against the risk of LBW, PTB, and SGA.
650		4	\|a Vitamin D
650		4	\|a Pregnancy
650		4	\|a Birth outcomes
650		4	\|a Prospective study
650		4	\|a Meta-analysis
700	1		\|a Zhou, Leilei \|4 aut
700	1		\|a Wang, Shanshan \|4 aut
700	1		\|a Yin, Heng \|4 aut
700	1		\|a Yang, Xuefeng \|4 aut
700	1		\|a Hao, Liping \|0 (orcid)0000-0001-8844-0892 \|4 aut
773	0	8	\|i Enthalten in \|t European journal of nutrition \|d Springer Berlin Heidelberg, 1999 \|g 61(2022), 6 vom: 22. März, Seite 2881-2907 \|h Online-Ressource \|w (DE-627)254910963 \|w (DE-600)1463312-7 \|w (DE-576)091204844 \|x 1436-6215 \|7 nnns
773	1	8	\|g volume:61 \|g year:2022 \|g number:6 \|g day:22 \|g month:03 \|g pages:2881-2907
856	4	0	\|u https://dx.doi.org/10.1007/s00394-022-02866-3 \|z lizenzpflichtig \|3 Volltext
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_OLC
912			\|a GBV_ILN_11
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_32
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_120
912			\|a GBV_ILN_138
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_152
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_267
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_647
912			\|a GBV_ILN_702
912			\|a GBV_ILN_711
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2018
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2134
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2144
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2188
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2446
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2474
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_2548
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4246
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4328
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4336
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
936	r	v	\|a ELIB10
936	r	v	\|a ELIB09
936	r	v	\|a ELIB24
936	b	k	\|a 44.21$jErnährung$XMedizin \|q VZ \|0 106409557 \|0 (DE-625)106409557
951			\|a AR
952			\|d 61 \|j 2022 \|e 6 \|b 22 \|c 03 \|h 2881-2907

Effect of maternal vitamin D status on risk of adverse birth outcomes: a systematic review and dose–response meta-analysis of observational studies

Zugang & Verfügbarkeit

Zugehörige Publikationen/Bände