Details der Publikation - Ring-shaped cataract and urinary metabolites among 2,4,6-trinitrotoluene exposed population of Pakistan

Ring-shaped cataract and urinary metabolites among 2,4,6-trinitrotoluene exposed population of Pakistan

Background Safety protocols are usually neglected among most of the trinitrotoluene (TNT)-exposed population, therefore, rendering the community prone to various occupational hazards. The current study highlights ring-shaped cataract and urinary metabolites of TNT among TNT-exposed population (n = 26) against a control group (n = 20). Method An observational case–control study was carried out in two groups: subjects exposed to TNT in Dir and Bajour Agency, Pakistan, and a control group from the base hospital. We determined the presence of ring-shaped cataract and urine metabolites of TNT using slit-lamp biomicroscope and gas chromatography–mass spectrometric analysis, respectively. Results Results substantiate a high level of urine metabolites for exposed subjects compared to the control group (p < 0.001). Age had no significant effect (p > 0.05) on the presence of ring-shaped cataract and the level of urinary metabolites of TNT, while duration of exposure showed significant effect (p < 0.001). Females showed high incidence of ring-shaped cataract and urinary metabolites of TNT than men ( p < 0.001). The mean age of the exposed subjects was 51 ± 14.38 (Mean ± SD) years. The mean year of exposure was 49 ± 5 (Mean ± SD) years. Conclusion This study showed TNT as a risk factor for the presence of ring-shaped cataract among TNT-exposed group in Pakistan. It is important to screen exposed community for the presence of ring-shaped cataract, and pre-clinical identification of TNT adducts to prevent systemic complications..

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:42
Enthalten in:	International ophthalmology - 42(2022), 8 vom: 26. März, Seite 2619-2624

Sprache:	Englisch

Beteiligte Personen:	Sarwat, Sidra [VerfasserIn] Akhtar, Ambreen [VerfasserIn] Dayan, Syeda Fizza Abdud [VerfasserIn] Shaheen, Najma [VerfasserIn] Durrani, Humna Shahid [VerfasserIn] Usman, Tariq [VerfasserIn] Afghani, Tayyab [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.95$jAugenheilkunde
Themen:	Ring-shaped cataract TNT exposure Urinary metabolites of TNT and 4-ADNT

Anmerkungen:	© The Author(s), under exclusive licence to Springer Nature B.V. 2022

doi:	10.1007/s10792-022-02252-2

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2131439377

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520			\|a Background Safety protocols are usually neglected among most of the trinitrotoluene (TNT)-exposed population, therefore, rendering the community prone to various occupational hazards. The current study highlights ring-shaped cataract and urinary metabolites of TNT among TNT-exposed population (n = 26) against a control group (n = 20). Method An observational case–control study was carried out in two groups: subjects exposed to TNT in Dir and Bajour Agency, Pakistan, and a control group from the base hospital. We determined the presence of ring-shaped cataract and urine metabolites of TNT using slit-lamp biomicroscope and gas chromatography–mass spectrometric analysis, respectively. Results Results substantiate a high level of urine metabolites for exposed subjects compared to the control group (p < 0.001). Age had no significant effect (p > 0.05) on the presence of ring-shaped cataract and the level of urinary metabolites of TNT, while duration of exposure showed significant effect (p < 0.001). Females showed high incidence of ring-shaped cataract and urinary metabolites of TNT than men ( p < 0.001). The mean age of the exposed subjects was 51 ± 14.38 (Mean ± SD) years. The mean year of exposure was 49 ± 5 (Mean ± SD) years. Conclusion This study showed TNT as a risk factor for the presence of ring-shaped cataract among TNT-exposed group in Pakistan. It is important to screen exposed community for the presence of ring-shaped cataract, and pre-clinical identification of TNT adducts to prevent systemic complications.
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Ring-shaped cataract and urinary metabolites among 2,4,6-trinitrotoluene exposed population of Pakistan

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