Details der Publikation - Dynamic relative regional strain visualized by electrical impedance tomography in patients suffering from COVID-19

Dynamic relative regional strain visualized by electrical impedance tomography in patients suffering from COVID-19

Abstract Respiratory failure due to SARS-CoV-2 may progress rapidly. During the course of COVID-19, patients develop an increased respiratory drive, which may induce high mechanical strain a known risk factor for Patient Self-Inflicted Lung Injury (P-SILI). We developed a novel Electrical Impedance Tomography-based approach to visualize the Dynamic Relative Regional Strain (DRRS) in SARS-CoV-2 positive patients and compared these findings with measurements in lung healthy volunteers. DRRS was defined as the ratio of tidal impedance changes and end-expiratory lung impedance within each pixel of the lung region. DRRS values of the ten patients were considerably higher than those of the ten healthy volunteers. On repeated examination, patterns, magnitude and frequency distribution of DRRS were reproducible and in line with the clinical course of the patients. Lung ultrasound scores correlated with the number of pixels showing DRRS values above the derived threshold. Using Electrical Impedance Tomography we were able to generate, for the first time, images of DRRS which might indicate P-SILI in patients suffering from COVID-19. Trial Registration This observational study was registered 06.04.2020 in German Clinical Trials Register (DRKS00021276)..

Medienart:	E-Artikel

Erscheinungsjahr:	2021
Erschienen:	2021

Enthalten in:	Zur Gesamtaufnahme - volume:36
Enthalten in:	Journal of clinical monitoring and computing - 36(2021), 4 vom: 13. Aug., Seite 975-985

Sprache:	Englisch

Beteiligte Personen:	Pulletz, Sven [VerfasserIn] Krukewitt, Lisa [VerfasserIn] Gonzales-Rios, Pablo [VerfasserIn] Teschendorf, Peter [VerfasserIn] Kremeier, Peter [VerfasserIn] Waldmann, Andreas [VerfasserIn] Zitzmann, Amelie [VerfasserIn] Müller-Graf, Fabian [VerfasserIn] Acosta, Cecilia [VerfasserIn] Tusman, Gerado [VerfasserIn] Reuter, Daniel A. [VerfasserIn] Böhm, Stephan H. [VerfasserIn]

Links:	Volltext [kostenfrei]

BKL:	44.09$jMedizintechnik 44.66$jAnästhesiologie
Themen:	COVID-19 DRRS Dynamic relative regional strain EIT Electrical impedance tomography Lung injury Strain

Anmerkungen:	© The Author(s) 2021

doi:	10.1007/s10877-021-00748-3

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2131360207

Internformat


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520			\|a Abstract Respiratory failure due to SARS-CoV-2 may progress rapidly. During the course of COVID-19, patients develop an increased respiratory drive, which may induce high mechanical strain a known risk factor for Patient Self-Inflicted Lung Injury (P-SILI). We developed a novel Electrical Impedance Tomography-based approach to visualize the Dynamic Relative Regional Strain (DRRS) in SARS-CoV-2 positive patients and compared these findings with measurements in lung healthy volunteers. DRRS was defined as the ratio of tidal impedance changes and end-expiratory lung impedance within each pixel of the lung region. DRRS values of the ten patients were considerably higher than those of the ten healthy volunteers. On repeated examination, patterns, magnitude and frequency distribution of DRRS were reproducible and in line with the clinical course of the patients. Lung ultrasound scores correlated with the number of pixels showing DRRS values above the derived threshold. Using Electrical Impedance Tomography we were able to generate, for the first time, images of DRRS which might indicate P-SILI in patients suffering from COVID-19. Trial Registration This observational study was registered 06.04.2020 in German Clinical Trials Register (DRKS00021276).
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650		4	\|a DRRS
700	1		\|a Krukewitt, Lisa \|4 aut
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700	1		\|a Tusman, Gerado \|4 aut
700	1		\|a Reuter, Daniel A. \|4 aut
700	1		\|a Böhm, Stephan H. \|4 aut
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Dynamic relative regional strain visualized by electrical impedance tomography in patients suffering from COVID-19

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