Details der Publikation - Alterations of circulating lymphocyte subsets in patients with colorectal carcinoma

Alterations of circulating lymphocyte subsets in patients with colorectal carcinoma

Introduction Cellular immune response to cancer is known to be of great importance for tumor control. Moreover, solid tumors influence circulating lymphocytes, which has been shown for several types of cancer. In our prospective study we elucidate changes in lymphocyte subsets in patients with colorectal carcinoma compared to healthy volunteers. Methods Flow cytometry was performed at diagnosis of colon carcinoma to analyze B cells, T cells and NK cells including various subtypes of each group. Univariate and multivariate analyses including age, gender, tumor stage, sidedness and microsatellite instability status (MSI) were performed. Results Forty-seven patients and 50 healthy volunteers were included. Median age was 65 years in patients and 43 years in the control group. Univariate analysis revealed lower total lymphocyte counts, lower CD4 + cells, CD8 + cells, B cells and NKs including various of their subsets in patients. In multivariate analysis patients had inferior values of B cells, CD4 + cells and NK cells and various subsets, regardless of age and gender. Naïve, central memory and HLADR + CD8 + cells showed an increase in patients whereas all other altered subsets declined. MSI status had no influence on circulating lymphocytes except for higher effector memory CD8 + cells in MSI-high patients. Localization in the left hemicolon led to higher values of total cytotoxic T cells and various T cell subsets. Conclusion We found significant changes in circulating lymphocyte subsets in colon carcinoma patients, independent of physiological alterations due to gender or age. For some lymphocyte subsets significant differences according to tumor localization or MSI-status could be seen..

Medienart:	E-Artikel

Erscheinungsjahr:	2021
Erschienen:	2021

Enthalten in:	Zur Gesamtaufnahme - volume:71
Enthalten in:	Cancer immunology immunotherapy - 71(2021), 8 vom: 20. Dez., Seite 1937-1947

Sprache:	Englisch

Beteiligte Personen:	Waidhauser, Johanna [VerfasserIn] Nerlinger, Pia [VerfasserIn] Arndt, Tim Tobias [VerfasserIn] Schiele, Stefan [VerfasserIn] Sommer, Florian [VerfasserIn] Wolf, Sebastian [VerfasserIn] Löhr, Phillip [VerfasserIn] Eser, Stefan [VerfasserIn] Müller, Gernot [VerfasserIn] Claus, Rainer [VerfasserIn] Märkl, Bruno [VerfasserIn] Rank, Andreas [VerfasserIn]

Links:	Volltext [kostenfrei]

BKL:	44.81$jOnkologie 44.45$jImmunologie
Themen:	Cellular immune status Circulating lymphocytes Colorectal carcinoma Flow cytometry Tumor immune response

RVK:	RVK Klassifikation ELIB24

Anmerkungen:	© The Author(s) 2021

doi:	10.1007/s00262-021-03127-8

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2131357613

Internformat


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245	1	0	\|a Alterations of circulating lymphocyte subsets in patients with colorectal carcinoma
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520			\|a Introduction Cellular immune response to cancer is known to be of great importance for tumor control. Moreover, solid tumors influence circulating lymphocytes, which has been shown for several types of cancer. In our prospective study we elucidate changes in lymphocyte subsets in patients with colorectal carcinoma compared to healthy volunteers. Methods Flow cytometry was performed at diagnosis of colon carcinoma to analyze B cells, T cells and NK cells including various subtypes of each group. Univariate and multivariate analyses including age, gender, tumor stage, sidedness and microsatellite instability status (MSI) were performed. Results Forty-seven patients and 50 healthy volunteers were included. Median age was 65 years in patients and 43 years in the control group. Univariate analysis revealed lower total lymphocyte counts, lower CD4 + cells, CD8 + cells, B cells and NKs including various of their subsets in patients. In multivariate analysis patients had inferior values of B cells, CD4 + cells and NK cells and various subsets, regardless of age and gender. Naïve, central memory and HLADR + CD8 + cells showed an increase in patients whereas all other altered subsets declined. MSI status had no influence on circulating lymphocytes except for higher effector memory CD8 + cells in MSI-high patients. Localization in the left hemicolon led to higher values of total cytotoxic T cells and various T cell subsets. Conclusion We found significant changes in circulating lymphocyte subsets in colon carcinoma patients, independent of physiological alterations due to gender or age. For some lymphocyte subsets significant differences according to tumor localization or MSI-status could be seen.
650		4	\|a Circulating lymphocytes
650		4	\|a Cellular immune status
650		4	\|a Colorectal carcinoma
650		4	\|a Tumor immune response
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700	1		\|a Nerlinger, Pia \|4 aut
700	1		\|a Arndt, Tim Tobias \|4 aut
700	1		\|a Schiele, Stefan \|4 aut
700	1		\|a Sommer, Florian \|4 aut
700	1		\|a Wolf, Sebastian \|4 aut
700	1		\|a Löhr, Phillip \|4 aut
700	1		\|a Eser, Stefan \|4 aut
700	1		\|a Müller, Gernot \|4 aut
700	1		\|a Claus, Rainer \|4 aut
700	1		\|a Märkl, Bruno \|4 aut
700	1		\|a Rank, Andreas \|4 aut
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773	1	8	\|g volume:71 \|g year:2021 \|g number:8 \|g day:20 \|g month:12 \|g pages:1937-1947
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Alterations of circulating lymphocyte subsets in patients with colorectal carcinoma

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