$ RuO_{2} $/rGO heterostructures as mimic peroxidases for colorimetric detection of glucose
The successful synthesis of ruthenium oxide/reduced graphene oxide ($ RuO_{2} $/rGO) heterostructures by one-pot hydrothermal method using graphene oxides and $ RuCl_{3} $ as precursors is reported. The heterostructures had high peroxidase-like (POD-like) activities, which catalyzes the oxidation of classical peroxidase substrate 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of $ H_{2} $$ O_{2} $ to create a blue colored reaction product. The catalytic activity was significantly enhanced by the synergistic effect between $ RuO_{2} $ nanoparticles and rGO. $ RuO_{2} $/rGO had a low $ K_{m} $ of 0.068 mM and a high $ v_{max} $ of 1.228 × $ 10^{−7} $ M·$ s^{−1} $ towards TMB in the TMB-$ H_{2} $$ O_{2} $ catalytic oxidation system. In addition, the POD-like activity originating from the electron transfer mechanism was confirmed by cytochrome C (Cyt C) oxidation experiment. A colorimetric method based on $ RuO_{2} $/rGO heterostructures was developed with good sensitivity and selectivity for glucose detection with a limit of detection of 3.34 μM and a linear range of 0–1500 μM. The $ RuO_{2} $/rGO heterostructures have potential applications in the biomedical areas, such as biosensor and diagnostics. Graphical abstract.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:189 |
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| Enthalten in: |
Microchimica acta - 189(2022), 7 vom: 21. Juni |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Haolin [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| BKL: | |
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| Themen: |
/rGO heterostructures |
| Anmerkungen: |
© The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2022 |
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| doi: |
10.1007/s00604-022-05319-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
OLC2131006314 |
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| 245 | 1 | 0 | |a $ RuO_{2} $/rGO heterostructures as mimic peroxidases for colorimetric detection of glucose |
| 264 | 1 | |c 2022 | |
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| 500 | |a © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2022 | ||
| 520 | |a The successful synthesis of ruthenium oxide/reduced graphene oxide ($ RuO_{2} $/rGO) heterostructures by one-pot hydrothermal method using graphene oxides and $ RuCl_{3} $ as precursors is reported. The heterostructures had high peroxidase-like (POD-like) activities, which catalyzes the oxidation of classical peroxidase substrate 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of $ H_{2} $$ O_{2} $ to create a blue colored reaction product. The catalytic activity was significantly enhanced by the synergistic effect between $ RuO_{2} $ nanoparticles and rGO. $ RuO_{2} $/rGO had a low $ K_{m} $ of 0.068 mM and a high $ v_{max} $ of 1.228 × $ 10^{−7} $ M·$ s^{−1} $ towards TMB in the TMB-$ H_{2} $$ O_{2} $ catalytic oxidation system. In addition, the POD-like activity originating from the electron transfer mechanism was confirmed by cytochrome C (Cyt C) oxidation experiment. A colorimetric method based on $ RuO_{2} $/rGO heterostructures was developed with good sensitivity and selectivity for glucose detection with a limit of detection of 3.34 μM and a linear range of 0–1500 μM. The $ RuO_{2} $/rGO heterostructures have potential applications in the biomedical areas, such as biosensor and diagnostics. Graphical abstract | ||
| 650 | 4 | |a RuO | |
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| 650 | 4 | |a Mimic enzyme | |
| 650 | 4 | |a Peroxidase-like activity | |
| 650 | 4 | |a Glucose detection | |
| 650 | 4 | |a Colorimetric detection | |
| 700 | 1 | |a Sun, Huiyuan |4 aut | |
| 700 | 1 | |a Ding, Jianwei |4 aut | |
| 700 | 1 | |a Wu, Ting |4 aut | |
| 700 | 1 | |a Cai, Shuangfei |4 aut | |
| 700 | 1 | |a Wang, Chen |4 aut | |
| 700 | 1 | |a Yang, Rong |4 aut | |
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