Details der Publikation - Aurothiomalate-Based Drugs as Potentially Novel Agents Against Leishmania major: A Mini Review

Aurothiomalate-Based Drugs as Potentially Novel Agents Against Leishmania major: A Mini Review

Purpose Leishmaniasis is a major public health problem worldwide in many parts of the world. Current anti-leishmanial drugs have only limited clinical efficacy. Aurothiomalate derivatives are useful for treating rheumatoid arthritis, but have emerged as a promising therapeutic candidate for leishmaniasis. This paper gives a review of the literature about the usefulness of aurothiomalate derivatives against leishmaniasis. Methods In this study, we reviewed the proposed mechanisms of action of aurothiomalate and related compounds on the metabolism of L. major and collected data by searching relevant articles. Results Aurothiomalate-based drugs could be effective against leishmaniasis through two direct and indirect mechanisms: first, cytotoxic effects on parasites via thiomalate’s false substrate role in the citric acid cycle against malate; and second, immunosuppressive and anti-inflammatory effects of aurothiomalate derivatives with prostaglandin production inhibitory effects. Conclusions The current study documented that aurothiomalate-based drugs could be effective against leishmaniasis through two direct and indirect mechanisms of action. Gold thiomalate as a promising hit should be evaluated against L. majorin vitro and in vivo conditions in the future..

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:67
Enthalten in:	Acta parasitologica - 67(2022), 2 vom: 05. Apr., Seite 640-647

Sprache:	Englisch

Beteiligte Personen:	Davoodi, Ali [VerfasserIn] Eslami, Shahram [VerfasserIn] Fakhar, Mahdi [VerfasserIn] Aazadbakht, Mohammad [VerfasserIn] Montazeri, Mahbobeh [VerfasserIn] Khoshvishkaie, Elnaz [VerfasserIn] Keighobadi, Masoud [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	42.36$jParasitologie$XBiologie 46.52$jInfektionskrankheiten$jparasitäre Krankheiten$XTiermedizin 44.75$jInfektionskrankheiten$jparasitäre Krankheiten$XMedizin
Themen:	Anti-leishmanial activity Aurothiomalate Fumarate hydratase Leishmaniasis S-2-thiomalate

Anmerkungen:	© The Author(s) under exclusive licence to Witold Stefański Institute of Parasitology, Polish Academy of Sciences 2022

doi:	10.1007/s11686-022-00536-2

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2130639631

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520			\|a Purpose Leishmaniasis is a major public health problem worldwide in many parts of the world. Current anti-leishmanial drugs have only limited clinical efficacy. Aurothiomalate derivatives are useful for treating rheumatoid arthritis, but have emerged as a promising therapeutic candidate for leishmaniasis. This paper gives a review of the literature about the usefulness of aurothiomalate derivatives against leishmaniasis. Methods In this study, we reviewed the proposed mechanisms of action of aurothiomalate and related compounds on the metabolism of L. major and collected data by searching relevant articles. Results Aurothiomalate-based drugs could be effective against leishmaniasis through two direct and indirect mechanisms: first, cytotoxic effects on parasites via thiomalate’s false substrate role in the citric acid cycle against malate; and second, immunosuppressive and anti-inflammatory effects of aurothiomalate derivatives with prostaglandin production inhibitory effects. Conclusions The current study documented that aurothiomalate-based drugs could be effective against leishmaniasis through two direct and indirect mechanisms of action. Gold thiomalate as a promising hit should be evaluated against L. majorin vitro and in vivo conditions in the future.
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Aurothiomalate-Based Drugs as Potentially Novel Agents Against Leishmania major: A Mini Review

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