Effects of inter-pregnancy intervals on preterm birth, low birth weight and perinatal deaths in urban South Ethiopia: a prospective cohort study
Background Preterm birth, low birth weight and perinatal deaths are common adverse perinatal outcomes that are linked with each other, and a public health problems contributing to neonatal mortality, especially in developing countries. Although more than half of women in Ethiopia become pregnant within a short interval after the preceding childbirth, whether the short intervals increase the risk of adverse perinatal outcomes or not is understudied. We, therefore, aimed to assess the effects of inter-pregnancy intervals (IPIs) on the adverse perinatal outcomes. Methods A community-based prospective cohort study was conducted among 2578 pregnant women in urban South Ethiopia. Pregnant women with IPIs < 24 months (IPIs < 18 and 18–23 months) were exposed groups, and those with IPI 24–60 months were the unexposed group. A multilevel analysis (mixed-effects) was done to estimate the effect of IPIs on preterm birth and low birth weight, and a generalized linear model for a binary outcome (fixed-effect) was done for perinatal deaths, using a 95% confidence level. Results In this study, IPI < 18 months found to increase the risk of preterm birth (Adjusted Relative Risk (ARR) = 1.35, 95% CI: 1.02, 1.78), term low birth weight (ARR = 2.20, 95% CI: 1.35, 3.58) and perinatal deaths (ARR = 3.83, 95% CI: 1.90, 7.71) than 24–60 months. The results suggest that, about 9% of preterm birth, 21% of term low birth weight and 41% of perinatal deaths in the study population were attributed to IPI < 18 months. These could be prevented with the removal of the IPI < 18 months in the study population. IPI 18–23 months has shown no effect on the three adverse perinatal outcomes. Conclusion This study has shown that, IPI under 18 months has a higher risk of adverse perinatal outcomes than IPI 24–60 months. Due attention should still be given for spacing pregnancies..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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| Enthalten in: |
Maternal health, neonatology and perinatology - 8(2022), 1 vom: 11. Mai |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jena, Belayneh Hamdela [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Cohort |
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| Anmerkungen: |
© The Author(s) 2022 |
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| doi: |
10.1186/s40748-022-00138-w |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
OLC2130448712 |
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| 520 | |a Background Preterm birth, low birth weight and perinatal deaths are common adverse perinatal outcomes that are linked with each other, and a public health problems contributing to neonatal mortality, especially in developing countries. Although more than half of women in Ethiopia become pregnant within a short interval after the preceding childbirth, whether the short intervals increase the risk of adverse perinatal outcomes or not is understudied. We, therefore, aimed to assess the effects of inter-pregnancy intervals (IPIs) on the adverse perinatal outcomes. Methods A community-based prospective cohort study was conducted among 2578 pregnant women in urban South Ethiopia. Pregnant women with IPIs < 24 months (IPIs < 18 and 18–23 months) were exposed groups, and those with IPI 24–60 months were the unexposed group. A multilevel analysis (mixed-effects) was done to estimate the effect of IPIs on preterm birth and low birth weight, and a generalized linear model for a binary outcome (fixed-effect) was done for perinatal deaths, using a 95% confidence level. Results In this study, IPI < 18 months found to increase the risk of preterm birth (Adjusted Relative Risk (ARR) = 1.35, 95% CI: 1.02, 1.78), term low birth weight (ARR = 2.20, 95% CI: 1.35, 3.58) and perinatal deaths (ARR = 3.83, 95% CI: 1.90, 7.71) than 24–60 months. The results suggest that, about 9% of preterm birth, 21% of term low birth weight and 41% of perinatal deaths in the study population were attributed to IPI < 18 months. These could be prevented with the removal of the IPI < 18 months in the study population. IPI 18–23 months has shown no effect on the three adverse perinatal outcomes. Conclusion This study has shown that, IPI under 18 months has a higher risk of adverse perinatal outcomes than IPI 24–60 months. Due attention should still be given for spacing pregnancies. | ||
| 650 | 4 | |a Inter-pregnancy interval | |
| 650 | 4 | |a Pregnant women | |
| 650 | 4 | |a Cohort | |
| 650 | 4 | |a Perinatal outcomes | |
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| 700 | 1 | |a Gete, Yigzaw Kebede |4 aut | |
| 700 | 1 | |a Gelaye, Kassahun Alemu |4 aut | |
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