Details der Publikation - Physical activity and glioma: a case–control study with follow-up for survival

Physical activity and glioma: a case–control study with follow-up for survival

Purpose High-grade disease accounts for ~ 70% of all glioma, and has a high mortality rate. Few modifiable exposures are known to be related to glioma risk or mortality. Methods We examined associations between lifetime physical activity and physical activity at different ages (15–18 years, 19–29 years, 30–39 years, last 10 years) with the risk of glioma diagnosis, using data from a hospital-based family case–control study (495 cases; 371 controls). We followed up cases over a median of 25 months to examine whether physical activity was associated with all-cause mortality. Physical activity and potential confounders were assessed by self-administered questionnaire. We examined associations between physical activity (metabolic equivalent [MET]-h/wk) and glioma risk using unconditional logistic regression and with all-cause mortality in cases using Cox regression. Results We noted a reduced risk of glioma for the highest (≥ 47 MET-h/wk) versus lowest (< 24 METh/wk) category of physical activity for lifetime activity (OR = 0.58, 95% CI: 0.38–0.89) and at 15–18 years (OR = 0.57, 95% CI: 0.39–0.83). We did not observe any association between physical activity and all-cause mortality (HR for lifetime physical activity = 0.91, 95% CI: 0.64–1.29). Conclusion Our findings are consistent with previous research that suggested physical activity during adolescence might be protective against glioma. Engaging in physical activity during adolescence has many health benefits; this health behavior may also offer protection against glioma..

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:33
Enthalten in:	Cancer causes & control - 33(2022), 5 vom: 20. Feb., Seite 749-757

Sprache:	Englisch

Beteiligte Personen:	Basiri, Zohreh [VerfasserIn] Yang, Yi [VerfasserIn] Bruinsma, Fiona J. [VerfasserIn] Nowak, Anna K. [VerfasserIn] McDonald, Kerrie L. [VerfasserIn] Drummond, Katharine J. [VerfasserIn] Rosenthal, Mark A. [VerfasserIn] Koh, Eng-Siew [VerfasserIn] Harrup, Rosemary [VerfasserIn] Hovey, Elizabeth [VerfasserIn] Joseph, David [VerfasserIn] Benke, Geza [VerfasserIn] Leonard, Robyn [VerfasserIn] MacInnis, Robert J. [VerfasserIn] Milne, Roger L. [VerfasserIn] Giles, Graham G. [VerfasserIn] Vajdic, Claire M. [VerfasserIn] Lynch, Brigid M. [VerfasserIn]

Links:	Volltext [kostenfrei]

BKL:	44.81$jOnkologie
Themen:	Case–control study Glioma Physical activity Survival

Anmerkungen:	© The Author(s) 2022

doi:	10.1007/s10552-022-01559-w

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC213015509X

Internformat


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520			\|a Purpose High-grade disease accounts for ~ 70% of all glioma, and has a high mortality rate. Few modifiable exposures are known to be related to glioma risk or mortality. Methods We examined associations between lifetime physical activity and physical activity at different ages (15–18 years, 19–29 years, 30–39 years, last 10 years) with the risk of glioma diagnosis, using data from a hospital-based family case–control study (495 cases; 371 controls). We followed up cases over a median of 25 months to examine whether physical activity was associated with all-cause mortality. Physical activity and potential confounders were assessed by self-administered questionnaire. We examined associations between physical activity (metabolic equivalent [MET]-h/wk) and glioma risk using unconditional logistic regression and with all-cause mortality in cases using Cox regression. Results We noted a reduced risk of glioma for the highest (≥ 47 MET-h/wk) versus lowest (< 24 METh/wk) category of physical activity for lifetime activity (OR = 0.58, 95% CI: 0.38–0.89) and at 15–18 years (OR = 0.57, 95% CI: 0.39–0.83). We did not observe any association between physical activity and all-cause mortality (HR for lifetime physical activity = 0.91, 95% CI: 0.64–1.29). Conclusion Our findings are consistent with previous research that suggested physical activity during adolescence might be protective against glioma. Engaging in physical activity during adolescence has many health benefits; this health behavior may also offer protection against glioma.
650		4	\|a Physical activity
650		4	\|a Glioma
650		4	\|a Case–control study
650		4	\|a Survival
700	1		\|a Yang, Yi \|4 aut
700	1		\|a Bruinsma, Fiona J. \|4 aut
700	1		\|a Nowak, Anna K. \|4 aut
700	1		\|a McDonald, Kerrie L. \|4 aut
700	1		\|a Drummond, Katharine J. \|4 aut
700	1		\|a Rosenthal, Mark A. \|4 aut
700	1		\|a Koh, Eng-Siew \|4 aut
700	1		\|a Harrup, Rosemary \|4 aut
700	1		\|a Hovey, Elizabeth \|4 aut
700	1		\|a Joseph, David \|4 aut
700	1		\|a Benke, Geza \|4 aut
700	1		\|a Leonard, Robyn \|4 aut
700	1		\|a MacInnis, Robert J. \|4 aut
700	1		\|a Milne, Roger L. \|4 aut
700	1		\|a Giles, Graham G. \|4 aut
700	1		\|a Vajdic, Claire M. \|4 aut
700	1		\|a Lynch, Brigid M. \|0 (orcid)0000-0001-8060-547X \|4 aut
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Physical activity and glioma: a case–control study with follow-up for survival

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