Details der Publikation - SARS-CoV-2 infection in dialysis and kidney transplant patients: immunological and serological response

SARS-CoV-2 infection in dialysis and kidney transplant patients: immunological and serological response

Background Dialysis and kidney transplant patients with moderate-severe COVID-19 have a high mortality rate, around 30%, that is similar in the two populations, despite differences in their baseline characteristics. In these groups, the immunology of the disease has been poorly explored. Methods Thirty-two patients on dialysis or with kidney transplant and SARS-CoV-2 infection requiring hospitalization (COV group) were included in our study. Lymphocyte subsets, dendritic cell (DC) counts and monocyte activation were studied. SARS-CoV-2 anti-spike/anti-nucleocapsid were monitored, and baseline cytokines and chemokines were measured in 10 patients. Results The COV group, compared to healthy subjects and uninfected dialysis/kidney transplant controls, showed lower numbers of CD4 + and CD8 + T cells, Natural-Killer (NK), B cells, plasmacytoid and myeloid DCs, while the proportion of terminally differentiated B-cells was increased. IL6, IL10, IFN-α and chemokines involved in monocyte and neutrophil recruitment were higher in the COV group, compared to uninfected dialysis/kidney transplant controls. Patients with severe disease had lower CD4 + , CD8 + and B-cell counts and lower monocyte HLA-DR expression. Of note, when comparing dialysis and kidney transplant patients with COVID-19, the latter group presented lower NK and pDC counts and monocyte HLA-DR expression. Up to 60 days after symptom onset, kidney transplant recipients showed lower levels of anti-spike antibodies compared to dialysis patients. Conclusions During SARS-CoV-2 infection, dialysis and kidney transplant patients manifest immunophenotype abnormalities; these are similar in the two groups, however kidney transplant recipients show more profound alterations of the innate immune system and lower anti-spike antibody response. Graphical abstract.

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:35
Enthalten in:	Journal of nephrology - 35(2022), 3 vom: 24. Jan., Seite 745-759

Sprache:	Englisch

Beteiligte Personen:	Alberici, Federico [VerfasserIn] Affatato, Stefania [VerfasserIn] Moratto, Daniele [VerfasserIn] Mescia, Federica [VerfasserIn] Delbarba, Elisa [VerfasserIn] Guerini, Alice [VerfasserIn] Tedesco, Martina [VerfasserIn] Burbelo, Peter D. [VerfasserIn] Zani, Roberta [VerfasserIn] Castagna, Ilaria [VerfasserIn] Gallico, Agnese [VerfasserIn] Tonoli, Mattia [VerfasserIn] Venturini, Margherita [VerfasserIn] Roccaro, Aldo M. [VerfasserIn] Giacomelli, Mauro [VerfasserIn] Cohen, Jeffrey I. [VerfasserIn] Giustini, Viviana [VerfasserIn] Dobbs, Kerry [VerfasserIn] Su, Helen C. [VerfasserIn] Fiorini, Chiara [VerfasserIn] Quaresima, Virginia [VerfasserIn] Viola, Fabio Battista [VerfasserIn] Vizzardi, Valerio [VerfasserIn] Gaggiotti, Mario [VerfasserIn] Bossini, Nicola [VerfasserIn] Gaggia, Paola [VerfasserIn] Badolato, Raffaele [VerfasserIn] Notarangelo, Luigi D. [VerfasserIn] Chiarini, Marco [VerfasserIn] Scolari, Francesco [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	COVID-19 Hemodialysis Kidney transplant Lymphocytes SARS-CoV-2

Anmerkungen:	© The Author(s) under exclusive licence to Italian Society of Nephrology 2021

doi:	10.1007/s40620-021-01214-8

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2130109721

Internformat


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520			\|a Background Dialysis and kidney transplant patients with moderate-severe COVID-19 have a high mortality rate, around 30%, that is similar in the two populations, despite differences in their baseline characteristics. In these groups, the immunology of the disease has been poorly explored. Methods Thirty-two patients on dialysis or with kidney transplant and SARS-CoV-2 infection requiring hospitalization (COV group) were included in our study. Lymphocyte subsets, dendritic cell (DC) counts and monocyte activation were studied. SARS-CoV-2 anti-spike/anti-nucleocapsid were monitored, and baseline cytokines and chemokines were measured in 10 patients. Results The COV group, compared to healthy subjects and uninfected dialysis/kidney transplant controls, showed lower numbers of CD4 + and CD8 + T cells, Natural-Killer (NK), B cells, plasmacytoid and myeloid DCs, while the proportion of terminally differentiated B-cells was increased. IL6, IL10, IFN-α and chemokines involved in monocyte and neutrophil recruitment were higher in the COV group, compared to uninfected dialysis/kidney transplant controls. Patients with severe disease had lower CD4 + , CD8 + and B-cell counts and lower monocyte HLA-DR expression. Of note, when comparing dialysis and kidney transplant patients with COVID-19, the latter group presented lower NK and pDC counts and monocyte HLA-DR expression. Up to 60 days after symptom onset, kidney transplant recipients showed lower levels of anti-spike antibodies compared to dialysis patients. Conclusions During SARS-CoV-2 infection, dialysis and kidney transplant patients manifest immunophenotype abnormalities; these are similar in the two groups, however kidney transplant recipients show more profound alterations of the innate immune system and lower anti-spike antibody response. Graphical abstract
650		4	\|a Hemodialysis
650		4	\|a Kidney transplant
650		4	\|a Lymphocytes
650		4	\|a SARS-CoV-2
650		4	\|a COVID-19
700	1		\|a Affatato, Stefania \|4 aut
700	1		\|a Moratto, Daniele \|4 aut
700	1		\|a Mescia, Federica \|4 aut
700	1		\|a Delbarba, Elisa \|4 aut
700	1		\|a Guerini, Alice \|4 aut
700	1		\|a Tedesco, Martina \|4 aut
700	1		\|a Burbelo, Peter D. \|4 aut
700	1		\|a Zani, Roberta \|4 aut
700	1		\|a Castagna, Ilaria \|4 aut
700	1		\|a Gallico, Agnese \|4 aut
700	1		\|a Tonoli, Mattia \|4 aut
700	1		\|a Venturini, Margherita \|4 aut
700	1		\|a Roccaro, Aldo M. \|4 aut
700	1		\|a Giacomelli, Mauro \|4 aut
700	1		\|a Cohen, Jeffrey I. \|4 aut
700	1		\|a Giustini, Viviana \|4 aut
700	1		\|a Dobbs, Kerry \|4 aut
700	1		\|a Su, Helen C. \|4 aut
700	1		\|a Fiorini, Chiara \|4 aut
700	1		\|a Quaresima, Virginia \|4 aut
700	1		\|a Viola, Fabio Battista \|4 aut
700	1		\|a Vizzardi, Valerio \|4 aut
700	1		\|a Gaggiotti, Mario \|4 aut
700	1		\|a Bossini, Nicola \|4 aut
700	1		\|a Gaggia, Paola \|4 aut
700	1		\|a Badolato, Raffaele \|4 aut
700	1		\|a Notarangelo, Luigi D. \|4 aut
700	1		\|a Chiarini, Marco \|4 aut
700	1		\|a Scolari, Francesco \|4 aut
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952			\|d 35 \|j 2022 \|e 3 \|b 24 \|c 01 \|h 745-759

SARS-CoV-2 infection in dialysis and kidney transplant patients: immunological and serological response

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