Details der Publikation - Mesenchymal Stem Cell Exosomes in the Treatment of Myocardial Infarction: a Systematic Review of Preclinical In Vivo Studies

Mesenchymal Stem Cell Exosomes in the Treatment of Myocardial Infarction: a Systematic Review of Preclinical In Vivo Studies

Several prior studies have highlighted the promise of mesenchymal stem cells (MSCs) as tools for treating myocardial infarction (MI) patients. While MSCs were initially thought to mediate post-MI repair through differentiation and replacement of injured cells, they are now thought to function by releasing exosomes carrying important cargos which can prevent apoptosis and facilitate revascularization in the context of MI. Herein, we comprehensively survey prior preclinical studies examining MSC-derived exosomes (MSC-Exos) utility for the repair of MI-related tissue injury. In total, 24 relevant studies were identified in the PubMed, Web of Science, Embase, and Cochrane Library databases as per the PRISMA guidelines. In most studies, exosome-treated rodents exhibited improved cardiac function and angiogenesis together with decreased apoptotic cell death. MSC-Exos thus offer beneficial therapeutic efficacy when treating MI injury. However, further work will be necessary to standardize experimental preclinical models and to validate these results. Graphical abstract This systematic review provides a comprehensive overview of previous preclinical studies on the utility of exosomes derived from mesenchymal stem cells (MSCs) in the repair of myocardial infarction (MI) injury..

Medienart:	E-Artikel

Erscheinungsjahr:	2021
Erschienen:	2021

Enthalten in:	Zur Gesamtaufnahme - volume:15
Enthalten in:	Journal of cardiovascular translational research - 15(2021), 2 vom: 05. Okt., Seite 317-339

Sprache:	Englisch

Beteiligte Personen:	Meng, Hui [VerfasserIn] Cheng, Weiting [VerfasserIn] Wang, Lei [VerfasserIn] Chen, Shiqi [VerfasserIn] Teng, Yu [VerfasserIn] Lu, Ziwen [VerfasserIn] Li, Yang [VerfasserIn] Zhao, Mingjing [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.85$jKardiologie$jAngiologie
Themen:	Angiogenesis Apoptosis Exosomes Mesenchymal stem cell Systematic review

Anmerkungen:	© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021

doi:	10.1007/s12265-021-10168-y

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2130042325

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Mesenchymal Stem Cell Exosomes in the Treatment of Myocardial Infarction: a Systematic Review of Preclinical In Vivo Studies

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