Details der Publikation - Low-entry-barrier point-of-care testing of anti-SARS-CoV-2 IgG in the population of Upper Austria from December 2020 until April 2021—a feasible surveillance strategy for post-pandemic monitoring?

Low-entry-barrier point-of-care testing of anti-SARS-CoV-2 IgG in the population of Upper Austria from December 2020 until April 2021—a feasible surveillance strategy for post-pandemic monitoring?

Already at the very beginning of the COVID-19 pandemic, an extensive PCR and antigen testing strategy was considered necessary and subsequently also proved successful in order to limit the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on international and national levels. However, equally important will be the continuous monitoring of the seroprevalence status of populations from defined regions to detect—in a timely manner—any recurrence of infections or an eventual decline in antibody levels of vaccinated individuals, especially in the emerging post-pandemic situation. The aim of this study was to estimate the prevalence of SARS-CoV-2-specific immunoglobulin G antibodies in the federal state of Upper Austria (Austria) during the period of December 2020 until April 2021. To achieve this goal, we have analyzed anonymized data on the immune status of self-referral volunteers that have been determined at local pharmacies through a low-entry-barrier point-of-care analysis approach. The seroprevalence values for immunoglobulin type G antibodies against SARS-CoV-2 antigens obtained by rapid diagnostic testing on peripheral blood from volunteers reflect the current population-based estimates reported in the literature as well as the positivity rates detected by PCR-screening analyses. In conclusion, broad-based monitoring of IgG antibodies by means of a point-of-care testing network represents a valuable tool to assess the current immune situation within regionally defined populations. Graphical abstract.

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:414
Enthalten in:	Analytical and bioanalytical chemistry - 414(2022), 10 vom: 28. Feb., Seite 3291-3299

Sprache:	Englisch

Beteiligte Personen:	Doppler, Christian [VerfasserIn] Feischl, Michael [VerfasserIn] Ganhör, Clara [VerfasserIn] Puh, Spela [VerfasserIn] Müller, Marina [VerfasserIn] Kotnik, Michaela [VerfasserIn] Mimler, Teresa [VerfasserIn] Sonnleitner, Max [VerfasserIn] Bernhard, David [VerfasserIn] Wechselberger, Christian [VerfasserIn]

Links:	Volltext [kostenfrei]

BKL:	35.23$jAnalytische Chemie: Allgemeines 35.71$jBiochemische Methoden 42.03$jMethoden und Techniken der Biologie
Themen:	COVID-19 Immunoglobulin Point-of-care Rapid test SARS-CoV-2 Surveillance

RVK:	RVK Klassifikation ELIB10

Anmerkungen:	© The Author(s) 2022

doi:	10.1007/s00216-022-03966-z

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2129915132

Internformat


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245	1	0	\|a Low-entry-barrier point-of-care testing of anti-SARS-CoV-2 IgG in the population of Upper Austria from December 2020 until April 2021—a feasible surveillance strategy for post-pandemic monitoring?
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520			\|a Already at the very beginning of the COVID-19 pandemic, an extensive PCR and antigen testing strategy was considered necessary and subsequently also proved successful in order to limit the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on international and national levels. However, equally important will be the continuous monitoring of the seroprevalence status of populations from defined regions to detect—in a timely manner—any recurrence of infections or an eventual decline in antibody levels of vaccinated individuals, especially in the emerging post-pandemic situation. The aim of this study was to estimate the prevalence of SARS-CoV-2-specific immunoglobulin G antibodies in the federal state of Upper Austria (Austria) during the period of December 2020 until April 2021. To achieve this goal, we have analyzed anonymized data on the immune status of self-referral volunteers that have been determined at local pharmacies through a low-entry-barrier point-of-care analysis approach. The seroprevalence values for immunoglobulin type G antibodies against SARS-CoV-2 antigens obtained by rapid diagnostic testing on peripheral blood from volunteers reflect the current population-based estimates reported in the literature as well as the positivity rates detected by PCR-screening analyses. In conclusion, broad-based monitoring of IgG antibodies by means of a point-of-care testing network represents a valuable tool to assess the current immune situation within regionally defined populations. Graphical abstract
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650		4	\|a COVID-19
650		4	\|a Rapid test
650		4	\|a Point-of-care
650		4	\|a Immunoglobulin
650		4	\|a Surveillance
700	1		\|a Feischl, Michael \|4 aut
700	1		\|a Ganhör, Clara \|4 aut
700	1		\|a Puh, Spela \|4 aut
700	1		\|a Müller, Marina \|4 aut
700	1		\|a Kotnik, Michaela \|4 aut
700	1		\|a Mimler, Teresa \|4 aut
700	1		\|a Sonnleitner, Max \|4 aut
700	1		\|a Bernhard, David \|4 aut
700	1		\|a Wechselberger, Christian \|4 aut
773	0	8	\|i Enthalten in \|t Analytical and bioanalytical chemistry \|d Springer Berlin Heidelberg, 2002 \|g 414(2022), 10 vom: 28. Feb., Seite 3291-3299 \|h Online-Ressource \|w (DE-627)25372337X \|w (DE-600)1459122-4 \|w (DE-576)072372842 \|x 1618-2650 \|7 nnns
773	1	8	\|g volume:414 \|g year:2022 \|g number:10 \|g day:28 \|g month:02 \|g pages:3291-3299
856	4	0	\|u https://dx.doi.org/10.1007/s00216-022-03966-z \|z kostenfrei \|3 Volltext
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912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
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Low-entry-barrier point-of-care testing of anti-SARS-CoV-2 IgG in the population of Upper Austria from December 2020 until April 2021—a feasible surveillance strategy for post-pandemic monitoring?

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