Functional status in older patients with lung cancer: an observational cohort study

Purpose An assessment of the impact of functional status (FS) evaluated using a combination of Activities of Daily Living (ADL) and the short version of the Instrumental Activities of Daily Living (IADL), on 3- and 6- month mortality and on 3-month unplanned hospitalizations in older patients treated for lung cancers. Method and objectives This observational retrospective study was conducted between September 2015 and January 2019 at Marseille University Hospital (AP-HM). During this period, all consecutive outpatients aged 70 years or older referred for a comprehensive geriatric assessment (CGA) before the initiation of lung cancer treatment were enrolled. Results Two hundred twenty-seven patients were analyzed: the median age was 78.7 years and 74.0% were male. Almost half of the patients were metastatic (45.4%). Concerning FS, 41.9% of patients had no ADL-IADL impairment, 30.0% had either IADL or ADL impairment, and both ADL-IADL were impaired for 28.1%. Impaired ADL-IADL was associated with poor nutritional status, depression, mobility, and cognitive disorders. In a logistic regression model, ADL or IADL impairment (aOR = 2.1; 95% CI [1.0–4.2]; p = 0.037) and impaired ADL-IADL (aOR = 2.6; 95% CI [1.2–5.3]; p = 0.012) were independently associated with a higher risk of unplanned hospitalizations within 3 months. In the multivariate Cox model, 6-month mortality risk was independently associated with impaired ADL-IADL (aHR = 2.3; 95% CI [1.3–4.4]; p = 0.008). Conclusion The combination of ADL and IADL scales to assess FS is a prognostic marker of the mortality risk at 6 months in older patients with lung cancer and should be more largely used by oncologists in treatment decision making..

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:30

Enthalten in:

Supportive care in cancer - 30(2022), 5 vom: 15. Jan., Seite 3817-3827

Sprache:

Englisch

Beteiligte Personen:

Couderc, Anne-Laure [VerfasserIn]
Tomasini, Pascale [VerfasserIn]
Greillier, Laurent [VerfasserIn]
Nouguerède, Emilie [VerfasserIn]
Rey, Dominique [VerfasserIn]
Montegut, Coline [VerfasserIn]
Thomas, Pascal-Alexandre [VerfasserIn]
Barlesi, Fabrice [VerfasserIn]
Villani, Patrick [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

Themen:

Aged
Cancer treatment protocols
Daily living activities
Functional status
Lung cancer
Mortality

RVK:

RVK Klassifikation

Anmerkungen:

© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021

doi:

10.1007/s00520-021-06752-2

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2129887317

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