Details der Publikation - Expert Opinion on Pegloticase with Concomitant Immunomodulatory Therapy in the Treatment of Uncontrolled Gout to Improve Efficacy, Safety, and Durability of Response

Expert Opinion on Pegloticase with Concomitant Immunomodulatory Therapy in the Treatment of Uncontrolled Gout to Improve Efficacy, Safety, and Durability of Response

Purpose of Review Gout is a systemic disease from which some patients develop numerous painful tophi that adversely affect quality of life and functionality. Some patients treated with oral urate-lowering therapy are unable to maintain serum urate levels below 6 mg/dL, and these patients, thus classified as having refractory or uncontrolled gout, often require therapy with pegloticase to reduce symptoms and tophaceous burden. The objective of this expert opinion review is to summarize the available evidence supporting the use of concomitant immunomodulators with pegloticase to prevent development of anti-drug antibodies (ADAs) when treating patients with uncontrolled gout. Recent Findings Emerging evidence suggests that adding an immunomodulator to pegloticase therapy can substantially increase response rates to double those observed in phase 3 randomized controlled trials. Summary The combination of immunomodulation with pegloticase should be considered in routine clinical practice to improve durability of response, efficacy, and safety among patients with uncontrolled gout who otherwise have limited therapeutic options..

Medienart:	E-Artikel

Erscheinungsjahr:	2022
Erschienen:	2022

Enthalten in:	Zur Gesamtaufnahme - volume:24
Enthalten in:	Current rheumatology reports - 24(2022), 1 vom: Jan., Seite 12-19

Sprache:	Englisch

Beteiligte Personen:	Botson, John K. [VerfasserIn] Baraf, Herbert S. B. [VerfasserIn] Keenan, Robert T. [VerfasserIn] Albert, John [VerfasserIn] Masri, Karim R. [VerfasserIn] Peterson, Jeff [VerfasserIn] Yung, Christianne [VerfasserIn] Freyne, Brigid [VerfasserIn] Amin, Mona [VerfasserIn] Abdellatif, Abdul [VerfasserIn] Soloman, Nehad [VerfasserIn] Edwards, N. Lawrence [VerfasserIn] Strand, Vibeke [VerfasserIn]

Links:	Volltext [kostenfrei]

BKL:	44.83$jRheumatologie$jOrthopädie
Themen:	Antidrug antibodies Gout Immunogenicity Immunomodulation Pegloticase

Anmerkungen:	© The Author(s) 2022

doi:	10.1007/s11926-022-01055-9

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2129548024

Internformat


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520			\|a Purpose of Review Gout is a systemic disease from which some patients develop numerous painful tophi that adversely affect quality of life and functionality. Some patients treated with oral urate-lowering therapy are unable to maintain serum urate levels below 6 mg/dL, and these patients, thus classified as having refractory or uncontrolled gout, often require therapy with pegloticase to reduce symptoms and tophaceous burden. The objective of this expert opinion review is to summarize the available evidence supporting the use of concomitant immunomodulators with pegloticase to prevent development of anti-drug antibodies (ADAs) when treating patients with uncontrolled gout. Recent Findings Emerging evidence suggests that adding an immunomodulator to pegloticase therapy can substantially increase response rates to double those observed in phase 3 randomized controlled trials. Summary The combination of immunomodulation with pegloticase should be considered in routine clinical practice to improve durability of response, efficacy, and safety among patients with uncontrolled gout who otherwise have limited therapeutic options.
650		4	\|a Antidrug antibodies
650		4	\|a Gout
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650		4	\|a Pegloticase
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700	1		\|a Peterson, Jeff \|4 aut
700	1		\|a Yung, Christianne \|4 aut
700	1		\|a Freyne, Brigid \|4 aut
700	1		\|a Amin, Mona \|4 aut
700	1		\|a Abdellatif, Abdul \|4 aut
700	1		\|a Soloman, Nehad \|4 aut
700	1		\|a Edwards, N. Lawrence \|4 aut
700	1		\|a Strand, Vibeke \|4 aut
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912			\|a GBV_ILN_100
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912			\|a GBV_ILN_110
912			\|a GBV_ILN_120
912			\|a GBV_ILN_138
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_152
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
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912			\|a GBV_ILN_230
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912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
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912			\|a GBV_ILN_2107
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912			\|a GBV_ILN_2110
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912			\|a GBV_ILN_4251
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912			\|a GBV_ILN_4328
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
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Expert Opinion on Pegloticase with Concomitant Immunomodulatory Therapy in the Treatment of Uncontrolled Gout to Improve Efficacy, Safety, and Durability of Response

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